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AB199594

Recombinant Human Protocadherin beta 12 protein

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Recombinant Human Protocadherin beta 12 protein is a Human Fragment protein, in the 27 to 690 aa range, expressed in Escherichia coli, with >90%, suitable for SDS-PAGE.

View Alternative Names

Protocadherin beta-12, PCDH-beta-12, PCDHB12

Key facts

Purity

>90% SDS-PAGE

Expression system

Escherichia coli

Tags

His tag N-Terminus

Applications

SDS-PAGE

applications

Biologically active

No

Accession

Q9Y5F1

Animal free

No

Carrier free

No

Species

Human

Storage buffer

pH: 8 Constituents: 0.32% Tris HCl

storage-buffer

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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Sequence info

[{"sequence":"MTLHRNEYGIASILDSYQCTAEISLADLATIFFAQFVQEATYKEVSKMVKDALTAIEKPTGDEQSSGCLENQLPAFLEELCHEKEILEKYGHSDCCSQSEEGRHNCFLAHKKPTPASIPLFQVPEPVTSCEAYEEDRETFMNKFIYEIARRHPFLYAPTILLWAARYDKIIPSCCKAENAVECFQTKAATVTKELRESSGGSHHHHHHGSENLYFQGSGSETGNFLVMEELQSGSFVGNLAKTLGLEVSELSSRGARVVSNDNKECLQLDTNTGDLLLREMLDREELCGSNEPCVLYFQVLMKNPTQFLQIELQVRDINDHSPVFLEKEMLLEIPENSPVGAVFLLESAKDLDVGINAVKSYTINPNSHFHVKIRVNPDNRKYPELVLDKALDYEERPELSFILTALDGGSPPRSGTALVRVVVVDINDNSPEFEQAFYEVKILENSILGSLVVTVSAWDLDSGTNSELSYTFSHASEDIRKTFEINQKSGDITLTAPLDFEAIESYSIIIQATDGGGLFGKSTVRIQVMDVNDNAPEITVSSITSPIPENTPETVVMVFRIRDRDSGDNGKMVCSIPEDIPFVLKSSVNNYYTLETERPLDRESRAEYNITITVTDLGTPRLKTEHNITVLVSDVNDNAPAFTQTSYALFVRENNSPALHIGSISATDRDSGTNAQVNYSLLPSQDPHLPLASLVSINADNGHLFALRSLDYEALQGFQFRVGATDHGSPALSSEALVRVLVLDANDNSPFVLYPLQNGSAPCTELVPWAAEPGYLVTKVVAVDGDSGQNAWLSYQLLKATEPGLFGVWAHNGEVRTARLLSERDAAKHRLVVLVKDNGEPPRSATATLHVLLVDGFSQPYLPLPEAAPAQAQADSLTVYL","proteinLength":"Fragment","predictedMolecularWeight":"97.35 kDa","actualMolecularWeight":null,"aminoAcidEnd":690,"aminoAcidStart":27,"nature":"Recombinant","expressionSystem":"Escherichia coli","accessionNumber":"Q9Y5F1","tags":[{"tag":"His","terminus":"N-Terminus"}]}]
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Properties and storage information

Shipped at conditions
Dry Ice
Appropriate short-term storage conditions
-80°C
Appropriate long-term storage conditions
-80°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
False
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Protocadherin beta 12 also known as PCDHB12 serves as a calcium-dependent cell-adhesion protein. It belongs to the protocadherin family and is one of the cadherin superfamily members. PCDHB12 has a predicted mass of approximately 87 kDa. This protein expresses itself predominantly in the brain tissues and plays a role in the development and maintenance of neural networks. In the cellular context PCDHB12 contributes to the establishment of specific cell-cell contact sites which are important in neuron function.
Biological function summary

The roles of PCDHB12 are essential in mediating calcium-dependent cell adhesion mechanisms. It does not function as part of any larger complexes but can interact with other similar protocadherins supporting cell sorting and carrying signals across synapses. PCDHB12 facilitates the cellular communication necessary for the organization of motor neurons and sensory pathways enabling appropriate signal transduction and maintaining proper neural circuit integrity.

Pathways

PCDHB12 contributes to neuronal pathways and synaptic adhesion processes. It aligns with signal transduction cascades related to synaptic formation and plasticity fundamental to learning and memory. PCDHB12 shares functional similarities with other protocadherins like PCDHA and PCDHG groups which participate in the cadherin-catenin signaling pathways. Together these proteins bolster intercellular adhesion and synaptic stability essential for proper central nervous system function.

Abnormal expression or mutation of PCDHB12 links to neurological diseases particularly neurodevelopmental disorders and schizophrenia. The imbalance in PCDHB12 expression can disrupt neural connectivity and has associations with altered cognitive functions. Dysregulation of PCDHB12 may co-occur with abnormalities in proteins like PCDHA and PCDHG which are also implicated in neurological pathologies suggesting a broader role in neural development anomalies when any of these proteins malfunction.
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Specifications

Form

Liquid

Additional notes

Expressed in E.coli as inclusion bodies. The final product was refolded using unique “temperature shift inclusion body refolding” technology and chromatographically purified.

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General info

Function

Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain.

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Product protocols

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Target data

Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain.
See full target information PCDHB12
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