Recombinant Human PSMA8 protein (His tag N-Terminus)
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Recombinant Human PSMA8 protein (His tag N-Terminus) is a Human Full Length protein, in the 1 to 250 aa range, expressed in Escherichia coli, with >90%, suitable for SDS-PAGE, Mass Spec.
View Alternative Names
PSMA7L, PSMA8, Proteasome subunit alpha-type 8, Proteasome alpha 4 subunit, Proteasome subunit alpha-type 7-like, Alpha4s
- SDS-PAGE
Unknown
SDS-PAGE - Recombinant Human PSMA8 protein (His tag N-Terminus) (AB116154)
15% SDS-PAGE showing ab116154 at approximately 30kDa (3µg).
Reactivity data
Sequence info
Properties and storage information
Shipped at conditions
Appropriate short-term storage duration
Appropriate short-term storage conditions
Appropriate long-term storage conditions
Aliquoting information
Storage information
Supplementary information
This supplementary information is collated from multiple sources and compiled automatically.
Biological function summary
This proteasome subunit is a part of the 20S core complex of the proteasome contributing to the selective degradation of proteins in cells. Its function is key in male germ cell development facilitating the proper progression through spermatogenesis. PSMA8 by regulating protein turnover ensures that regulatory proteins are degraded at the right time allowing for the orderly progression of cellular processes essential for germ cell maturation and fertility.
Pathways
PSMA8 engages in pathways associated with protein degradation alongside related proteasome components. It participates in the ubiquitin-proteasome pathway a vital cellular mechanism for protein catabolism. This pathway works closely with the ubiquitin system to tag proteins for degradation involving proteins such as ubiquitin-conjugating enzymes and ligases. Furthermore PSMA8 might influence pathways linked to cell cycle and apoptosis by regulating levels of proteins that control these processes.
Specifications
Form
Liquid
Additional notes
ab116154 is purified using conventional chromatography techniques.
General info
Function
Component of the spermatoproteasome, a proteasome specifically found in testis that promotes acetylation-dependent degradation of histones, thereby participating actively to the exchange of histones during spermatogenesis. The proteasome is a protein complex that degrades unneeded or damaged proteins by proteolysis, a chemical reaction that breaks peptide bonds. Required for 20S core proteasome assembly, essential for the degradation of meiotic proteins RAD51 and RPA1 at late prophase I and the progression of meiosis I during spermatogenesis. Localizes to the synaptonemal complex, a 'zipper'-like structure that holds homologous chromosome pairs in synapsis during meiotic prophase I.
Sequence similarities
Belongs to the peptidase T1A family.
Subcellular localisation
Nucleus
Target data
Complementary Products
Product promise
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