Recombinant Human PSMB4 protein
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Recombinant Human PSMB4 protein is a Human Full Length protein, in the 46 to 264 aa range, expressed in Escherichia coli, with >90%, suitable for SDS-PAGE, Mass Spec.
View Alternative Names
PROS26, PSMB4, Proteasome subunit beta type-4, 26 kDa prosomal protein, Macropain beta chain, Multicatalytic endopeptidase complex beta chain, Proteasome beta chain, Proteasome chain 3, Proteasome subunit beta-7, HsBPROS26, PROS-26, HsN3, beta-7
- SDS-PAGE
Unknown
SDS-PAGE - Recombinant Human PSMB4 protein (AB115721)
15% SDS-PAGE showing ab115721 at approximately 26.6kDa (3μg).
Reactivity data
Product details
Sequence info
Properties and storage information
Shipped at conditions
Appropriate short-term storage duration
Appropriate short-term storage conditions
Appropriate long-term storage conditions
Aliquoting information
Storage information
Supplementary information
This supplementary information is collated from multiple sources and compiled automatically.
Biological function summary
The 20S proteasome where PSMB4 belongs acts as the proteolytic core of the 26S proteasome complex. This complex degrades unwanted or damaged proteins thereby regulating various cellular processes such as the cell cycle apoptosis and DNA repair. PSMB4's activity ensures the removal of potentially toxic proteins which is important for cell function and survival.
Pathways
PSMB4 is involved in key pathways such as the ubiquitin-proteasome pathway and antigen processing. These pathways regulate protein metabolism and assist in immune surveillance by presenting endogenous antigens through MHC class I molecules. PSMB4 interacts closely with other proteasome subunits like PSMB5 and PSMB6 which coordinate to cleave peptide bonds in substrate proteins effectively.
Specifications
Form
Liquid
Additional notes
ab115721 was purified using conventional chromatography techniques.
General info
Function
Non-catalytic component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex). SMAD1/OAZ1/PSMB4 complex mediates the degradation of the CREBBP/EP300 repressor SNIP1.
Sequence similarities
Belongs to the peptidase T1B family.
Subcellular localisation
Nucleus
Target data
Complementary Products
Product promise
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