Recombinant Human PSMD13 protein (denatured) (His tag N-Terminus)
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Recombinant Human PSMD13 protein (denatured) (His tag N-Terminus) is a Human Full Length protein, in the 1 to 376 aa range, expressed in Escherichia coli, with >90%, suitable for SDS-PAGE.
View Alternative Names
26S proteasome non-ATPase regulatory subunit 13, 26S proteasome regulatory subunit RPN9, 26S proteasome regulatory subunit S11, 26S proteasome regulatory subunit p40.5, PSMD13
- SDS-PAGE
Supplier Data
SDS-PAGE - Recombinant Human PSMD13 protein (denatured) (His tag N-Terminus) (AB181912)
3ug by SDS-PAGE under reducing conditions and visualized by coomassie blue stain.
Reactivity data
Sequence info
Properties and storage information
Shipped at conditions
Appropriate short-term storage duration
Appropriate short-term storage conditions
Appropriate long-term storage conditions
Aliquoting information
Storage information
Supplementary information
This supplementary information is collated from multiple sources and compiled automatically.
Biological function summary
Within the proteasome complex PSMD13 serves as a regulatory factor that assists in substrate recognition and unfolds misfolded proteins for degradation. As part of the 26S proteasome it associates with other regulatory subunits to modulate protein breakdown efficiently. This process is essential for maintaining protein homeostasis within cells allowing effective recycling of amino acids and removal of damaged or excessive proteins.
Pathways
The activity of PSMD13 is integral in the ubiquitin-proteasome pathway. This pathway is important for regulating the cellular protein quality control and turnover. PSMD13 is also involved in the NF-kB signaling pathway where it indirectly influences the activation of transcription factor NF-kB by controlling the degradation of IkB an inhibitor protein. It works with proteins like PSMD2 which cooperate in the function and efficiency of these pathways for cell regulation.
Specifications
Form
Liquid
General info
Function
Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair.
Sequence similarities
Belongs to the proteasome subunit S11 family.
Target data
Complementary Products
Product promise
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