JavaScript is disabled in your browser. Please enable JavaScript to view this website.
AB124605

Recombinant Human PTGR2 protein

Be the first to review this product! Submit a review

|

(0 Publication)

Recombinant Human PTGR2 protein is a Human Full Length protein, in the 1 to 351 aa range, expressed in Escherichia coli, with >90%, suitable for SDS-PAGE, Mass Spec.

View Alternative Names

ZADH1, PTGR2, Prostaglandin reductase 2, PRG-2, 15-oxoprostaglandin 13-reductase, Zinc-binding alcohol dehydrogenase domain-containing protein 1

1 Images
SDS-PAGE - Recombinant Human PTGR2 protein (AB124605)
  • SDS-PAGE

Supplier Data

SDS-PAGE - Recombinant Human PTGR2 protein (AB124605)

Key facts

Purity

>90% SDS-PAGE

Expression system

Escherichia coli

Tags

His tag N-Terminus

Applications

SDS-PAGE, Mass Spec

applications

Biologically active

No

Accession

Q8N8N7

Animal free

No

Carrier free

No

Species

Human

Storage buffer

pH: 8 Constituents: 10% Glycerol (glycerin, glycerine), 0.32% Tris HCl, 0.29% Sodium chloride, 0.02% (R*,R*)-1,4-Dimercaptobutan-2,3-diol

storage-buffer

style
left-column

Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "Mass Spec": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
style
left-column
style
left-column

Product details

This product was previously labelled as ZADH1
style
left-column

Sequence info

[{"sequence":"MGSSHHHHHHSSGLVPRGSHMGSHMIVQRVVLNSRPGKNGNPVAENFRMEEVYLPDNINEGQVQVRTLYLSVDPYMRCRMNEDTGTDYITPWQLSQVVDGGGIGIIEESKHTNLTKGDFVTSFYWPWQTKVILDGNSLEKVDPQLVDGHLSYFLGAIGMPGLTSLIGIQEKGHITAGSNKTMVVSGAAGACGSVAGQIGHFLGCSRVVGICGTHEKCILLTSELGFDAAINYKKDNVAEQLRESCPAGVDVYFDNVGGNISDTVISQMNENSHIILCGQISQYNKDVPYPPPLSPAIEAIQKERNITRERFLVLNYKDKFEPGILQLSQWFKEGKLKIKETVINGLENMGAAFQSMMTGGNIGKQIVCISEEISL","proteinLength":"Full Length","predictedMolecularWeight":"41.1 kDa","actualMolecularWeight":null,"aminoAcidEnd":351,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"Escherichia coli","accessionNumber":"Q8N8N7","tags":[{"tag":"His","terminus":"N-Terminus"}]}]
style
left-column

Properties and storage information

Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
False
style
left-column

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

PTGR2 also known as Prostaglandin Reductase 2 is an enzyme with a molecular weight of approximately 37 kDa. The enzyme catalyzes the reduction of 15-keto prostaglandins into more inactive forms. PTGR2 is widely expressed in various tissues with higher levels observed in the liver and kidney. Its function involves balancing the levels of prostaglandins which are important lipid compounds in the human body.
Biological function summary

PTGR2 plays a significant role in modulating inflammatory responses and cellular processes by regulating prostaglandin metabolism. The enzyme does not function as part of a larger protein complex acting independently to convert active prostaglandins into their less active forms. By doing so PTGR2 indirectly influences inflammation and other cellular responses triggered by prostaglandins.

Pathways

This enzyme contributes significantly to prostaglandin metabolic pathways. PTGR2's activity impacts the cycle involving oxidative degradation of prostaglandins which in turns affect inflammation and immune system responses. It works alongside proteins such as PTGR1 and enzymes linked with arachidonic acid metabolism essential in prostaglandin biosynthesis and degradation pathways.

PTGR2 implicates itself in conditions related to inflammation and cancer. Increased activity of PTGR2 has been linked to the progression of certain cancers such as colorectal cancer due to its role in altering local concentrations of prostaglandins that influence tumor growth. PTGR2's regulation of prostaglandins also associates it with inflammatory diseases as abnormal prostaglandin levels can exacerbate these conditions. Connections with proteins like COX-2 emphasize its significance in these diseases as COX-2 plays a pivotal role in prostaglandin synthesis.
style
left-column

Specifications

Form

Liquid

Additional notes

ab124605 is purified by using conventional chromatography techniques.

style
left-column

General info

Function

Functions as 15-oxo-prostaglandin 13-reductase and acts on 15-keto-PGE1, 15-keto-PGE2, 15-keto-PGE1-alpha and 15-keto-PGE2-alpha with highest activity towards 15-keto-PGE2 (PubMed : 19000823). Overexpression represses transcriptional activity of PPARG and inhibits adipocyte differentiation (By similarity).

Sequence similarities

Belongs to the NADP-dependent oxidoreductase L4BD family.

style
left-column

Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
style
left-column

Target data

Functions as 15-oxo-prostaglandin 13-reductase and acts on 15-keto-PGE1, 15-keto-PGE2, 15-keto-PGE1-alpha and 15-keto-PGE2-alpha with highest activity towards 15-keto-PGE2 (PubMed : 19000823). Overexpression represses transcriptional activity of PPARG and inhibits adipocyte differentiation (By similarity).
See full target information PTGR2
style
left-column
style
left-column

Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.
For full details, please see our Terms & Conditions
style
left-column
style
right-column
style
bg-slate-100

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com