Recombinant Human PTMS protein

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Prothymosin alpha (often abbreviated as 'PTMS' 'p.t.m.s' or 'ProTα') is a small highly acidic protein with a molecular mass of approximately 12 kDa. PTMS is ubiquitously expressed in various tissues with higher levels noted in thymus liver and spleen. The protein is known to reside predominantly in the nucleus where it performs multiple regulatory roles. PTMS undergoes selective expression changes depending on the developmental stage or physiological condition indicating its relevance across different contexts.

Biological function summary

PTMS interacts with various cellular structures to participate in chromatin remodeling and gene expression regulation. PTMS is known to engage in the formation of macro molecular complexes affecting nucleosome assembly and stability by binding histones and other nuclear proteins. Additionally PTMS plays a role in cell proliferation apoptosis and immune response modulation making it influential in several biological processes.

Pathways

PTMS participates in the regulation of the immune response and cell cycle progression. Within the immune response pathway PTMS contributes to the maturation and differentiation of T-cells by influencing the transcriptional machinery. In cell cycle pathways PTMS interacts with proteins such as c-Myc enhancing its function and promoting the transition from G1 to S phase. The involvement in these pathways illustrates its significance in maintaining cellular homeostasis and response to external stimuli.

PTMS shows a strong link with several cancer types and autoimmune disorders. In cancer overexpression of PTMS correlates with increased tumor development and progression where its interaction with oncogenic proteins like c-Myc promotes aberrant cell growth. In autoimmune disorders the dysregulation of PTMS might contribute to inappropriate immune responses suggesting a possible connection with proteins involved in immune regulation such as NF-kB. Understanding PTMS's role in these conditions could help in developing targeted therapeutic approaches.