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AB268902

Recombinant human PTPN13/FAP-1 protein (Active)

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Recombinant human PTPN13/FAP-1 protein (Active) is a Human Fragment protein, in the 2169 to 2485 aa range, expressed in Escherichia coli, with >90%, suitable for SDS-PAGE, FuncS.

View Alternative Names

PNP1, PTP1E, PTPL1, PTPN13, Tyrosine-protein phosphatase non-receptor type 13, Fas-associated protein-tyrosine phosphatase 1, PTP-BAS, Protein-tyrosine phosphatase 1E, Protein-tyrosine phosphatase PTPL1, FAP-1, PTP-E1, hPTPE1

2 Images
Functional Studies - Recombinant human PTPN13/FAP-1 protein (Active) (AB268902)
  • FuncS

Supplier Data

Functional Studies - Recombinant human PTPN13/FAP-1 protein (Active) (AB268902)

The specific activity of ab268902 was 2443 nmol/min/mg in a phosphatase assay using pNPP substrate.

SDS-PAGE - Recombinant human PTPN13/FAP-1 protein (Active) (AB268902)
  • SDS-PAGE

Supplier Data

SDS-PAGE - Recombinant human PTPN13/FAP-1 protein (Active) (AB268902)

SDS-PAGE analysis of ab268902.

Key facts

Purity

>90% SDS-PAGE

Expression system

Escherichia coli

Tags

GST tag N-Terminus

Applications

FuncS, SDS-PAGE

applications

Biologically active

Yes

Biological activity

The specific activity of ab268902 was 2443 nmol/min/mg in a phosphatase assay using pNPP substrate.

Accession

Q12923

Animal free

No

Carrier free

No

Species

Human

Storage buffer

pH: 7.5 Constituents: 30% Glycerol (glycerin, glycerine), 0.42% MOPS, 0.31% Glutathione, 0.29% Sodium chloride, 0.004% (R*,R*)-1,4-Dimercaptobutan-2,3-diol, 0.002% PMSF

storage-buffer

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "FuncS": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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Sequence info

[{"sequence":"DHSFLTNDELAVLPVVKVLPSGKYTGANLKSVIRVLRGLLDQGIPSKELENLQELKPLDQCLIGQTKENRRKNRYKNILPYDATRVPLGDEGGYINASFIKIPVGKEEFVYIACQGPLPTTVGDFWQMIWEQKSTVIAMMTQEVEGEKIKCQRYWPNILGKTTMVSNRLRLALVRMQQLKGFVVRAMTLEDIQTREVRHISHLNFTAWPDHDTPSQPDDLLTFISYMRHIHRSGPIITHCSAGIGRSGTLICIDVVLGLISQDLDFDISDLVRCMRLQRHGMVQTEDQYIFCYQVILYVLTRLQAEEEQKQQPQLLK","proteinLength":"Fragment","predictedMolecularWeight":null,"actualMolecularWeight":null,"aminoAcidEnd":2485,"aminoAcidStart":2169,"nature":"Recombinant","expressionSystem":"Escherichia coli","accessionNumber":"Q12923","tags":[{"tag":"GST","terminus":"N-Terminus"}]}]
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Properties and storage information

Shipped at conditions
Dry Ice
Appropriate short-term storage conditions
-80°C
Appropriate long-term storage conditions
-80°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
True
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

PTPN13 also known as FAP-1 or Fas-associated phosphatase-1 is a non-receptor type protein tyrosine phosphatase with a reported molecular weight of approximately 270 kDa. This enzyme contains several PDZ domains contributing to its interactions with other proteins. PTPN13 is expressed in various tissues including the brain liver and heart indicating its wide-ranging roles in cellular functions.
Biological function summary

PTPN13 plays a critical role in the regulation of apoptosis and cell-cell adhesion. It interacts with components of the cytoskeleton and other signaling proteins functioning as part of protein complexes involved in maintaining cellular structure and signaling. By dephosphorylating specific phosphotyrosine residues PTPN13 controls signaling pathways that determine cell survival and communication.

Pathways

PTPN13 is involved in pathways such as the Fas-mediated apoptosis signaling and insulin signaling pathways. It interacts with proteins like the Fas receptor and IRS1 within these pathways modulating signals that control apoptosis and metabolic responses. PTPN13's activity can affect downstream signaling events influencing cellular outcomes like survival or death in response to external stimuli.

Researchers have linked PTPN13 with cancer and insulin resistance. The protein's interaction with Fas-associated proteins suggests a role in tumorigenesis particularly related to apoptosis evasion. In the context of metabolic disorders PTPN13's function in the insulin signaling pathway connects it to insulin resistance where its regulation of IRS1 affects insulin response. These associations highlight the potential of targeting PTPN13 in therapeutic strategies for these diseases.
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Specifications

Form

Liquid

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General info

Function

Tyrosine phosphatase which negatively regulates FAS-induced apoptosis and NGFR-mediated pro-apoptotic signaling (PubMed : 15611135). May regulate phosphoinositide 3-kinase (PI3K) signaling through dephosphorylation of PIK3R2 (PubMed : 23604317).

Sequence similarities

Belongs to the protein-tyrosine phosphatase family. Non-receptor class subfamily.

Subcellular localisation

Cytoskeleton

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Product protocols

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Target data

Tyrosine phosphatase which negatively regulates FAS-induced apoptosis and NGFR-mediated pro-apoptotic signaling (PubMed : 15611135). May regulate phosphoinositide 3-kinase (PI3K) signaling through dephosphorylation of PIK3R2 (PubMed : 23604317).
See full target information PTPN13
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Primary Antibodies

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Anti-PTPN13/FAP-1 antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-PTPN13/FAP-1 antibody (AB198882)

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Secondary Antibodies

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Immunocytochemistry/ Immunofluorescence - Goat Anti-Mouse IgG H&L (Alexa Fluor® 488) (AB150113)

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Primary Antibodies

AB7817

Anti-alpha smooth muscle Actin antibody [1A4]

KO Validated

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-alpha smooth muscle Actin antibody [1A4] (AB7817)

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