Recombinant human PTPN9 protein is a Human Fragment protein, in the 285 to 593 aa range, expressed in Escherichia coli, with >70% purity and suitable for Inhib.
A M T I Q E L V D Y V N A R Q K Q G I Y E E Y E D I R R E N P V G T F H C S M S P G N L E K N R Y G D V P C L D Q T R V K L T K R S G H T Q T D Y I N A S F M D G Y K Q K N A Y I G T Q G P L E N T Y R D F W L M V W E Q K V L V I V M T T R F E E G G R R K C G Q Y W P L E K D S R I R F G F L T V T N L G V E N M N H Y K K T T L E I H N T E E R Q K R Q V T H F Q F L S W P D Y G V P S S A A S L I D F L R V V R N Q Q S L A V S N M G A R S K G Q C P E P P I V V H C S A G I G R T G T F C S L D I C L A Q L E E L G T L N V F Q T V S R M R T Q R A F S I Q T P E Q Y Y F C Y K A I L E F A E K E G M V S S G Q N L L A V E S Q
| Application | Reactivity | Dilution info | Notes |
|---|---|---|---|
Application Inhib | Reactivity Reacts | Dilution info - | Notes Useful for the study of enzyme kinetics, regulation, to dephosphorylate target substrates and for screening inhibitors. |
Protein-tyrosine phosphatase that could participate in the transfer of hydrophobic ligands or in functions of the Golgi apparatus.
Tyrosine-protein phosphatase non-receptor type 9, Protein-tyrosine phosphatase MEG2, PTPase MEG2, PTPN9
Recombinant human PTPN9 protein is a Human Fragment protein, in the 285 to 593 aa range, expressed in Escherichia coli, with >70% purity and suitable for Inhib.
pH: 8
Constituents: 50% Glycerol (glycerin, glycerine), 0.394% Tris HCl, 0.392% Sodium chloride, 0.307% Glutathione, 0.0463% (R*,R*)-1,4-Dimercaptobutan-2,3-diol, 0.0104% Potassium chloride
Protein-tyrosine phosphatase that could participate in the transfer of hydrophobic ligands or in functions of the Golgi apparatus.
Belongs to the protein-tyrosine phosphatase family. Non-receptor class 3 subfamily.
This product is an active protein and may elicit a biological response in vivo, handle with caution.
PTPN9 also known as protein tyrosine phosphatase non-receptor type 9 or PTP Meg2 functions as a protein tyrosine phosphatase that plays a role in dephosphorylating tyrosine residues on target proteins. It possesses a molecular mass of approximately 55 kDa. PTPN9 is expressed in various tissues including the liver placenta and pancreas and it is particularly relevant in blood cells like lymphocytes.
This phosphatase regulates intracellular signaling related to cell proliferation differentiation and survival. PTPN9 participates in vesicular trafficking by binding to phosphatidylinositol lipids suggesting it might play a role in membrane-related processes. Though it does not usually form part of large stable complexes PTPN9 interacts dynamically with other proteins to regulate signal transduction.
PTPN9 takes part in signaling cascades involved in immune responses and cellular growth processes. It interacts within the MAPK (Mitogen-Activated Protein Kinase) pathway which is critical for transmitting growth signals. Additionally PTPN9 relates to proteins like Ras and Raf within these pathways impacting how signals regulate cellular responses to external stimuli.
Research has linked PTPN9 to cancer and immune-related conditions. In cancers such as leukemia its altered function may contribute to unchecked cell proliferation. In immune disorders PTPN9 affects signaling processes linked with cytokine production and immune cell regulation. For instance associations with SHP-1 another phosphatase have shown relevance in these contexts influencing outcomes in pathological states.
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