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AB42577

Recombinant human PTPN9 protein (GST tag N-Terminus)

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Recombinant human PTPN9 protein (GST tag N-Terminus) is a Human Fragment protein, in the 285 to 593 aa range, expressed in Escherichia coli, with >70%, suitable for Inhib, FuncS.

View Alternative Names

Tyrosine-protein phosphatase non-receptor type 9, Protein-tyrosine phosphatase MEG2, PTPase MEG2, PTPN9

Key facts

Purity

>70% SDS-PAGE

Expression system

Escherichia coli

Tags

GST tag N-Terminus

Applications

Inhib, FuncS

applications

Biologically active

Yes

Biological activity

Specific Activity: 2 U/ug. One unit will hydrolyze 1 nmol p-nitrophenyl phosphate per minute at pH 7.4 and 30C. Assay buffer: 50 mM HEPES, pH 7.4, 2 mM EDTA, 3mM DTT, 100 mM NaCl, 50 mM pNPP.

Accession

P43378

Animal free

No

Carrier free

No

Species

Human

Storage buffer

pH: 8 Constituents: 50% Glycerol (glycerin, glycerine), 0.394% Tris HCl, 0.392% Sodium chloride, 0.307% Glutathione, 0.0463% (R*,R*)-1,4-Dimercaptobutan-2,3-diol, 0.0104% Potassium chloride

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Complementary Products

Primary Antibodies

AB317499

Anti-PKC epsilon antibody [EPR28194-50] - BSA and Azide free

Recombinant|RabMAb

Western blot - Anti-PKC epsilon antibody [EPR28194-50] - BSA and Azide free (AB317499)

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Proteins & Peptides

AB90687

Recombinant Human Skp1 protein (Tag Free)

Western blot - Recombinant Human Skp1 protein (Tag Free) (AB90687)

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Primary Antibodies

AB182126

Anti-PKC delta antibody [EPR17075]

KO Validated|RabMAb|Recombinant|20ul selling size

Immunocytochemistry/ Immunofluorescence - Anti-PKC delta antibody [EPR17075] (AB182126)

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Proteins & Peptides

AB60849

Recombinant human PKC eta protein

Western blot - Recombinant human PKC eta protein (AB60849)

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "Inhib": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p>Useful for the study of enzyme kinetics, regulation, to dephosphorylate target substrates and for screening inhibitors.</p>" }, "FuncS": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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Sequence info

[{"sequence":"AMTIQELVDYVNARQKQGIYEEYEDIRRENPVGTFHCSMSPGNLEKNRYGDVPCLDQTRVKLTKRSGHTQTDYINASFMDGYKQKNAYIGTQGPLENTYRDFWLMVWEQKVLVIVMTTRFEEGGRRKCGQYWPLEKDSRIRFGFLTVTNLGVENMNHYKKTTLEIHNTEERQKRQVTHFQFLSWPDYGVPSSAASLIDFLRVVRNQQSLAVSNMGARSKGQCPEPPIVVHCSAGIGRTGTFCSLDICLAQLEELGTLNVFQTVSRMRTQRAFSIQTPEQYYFCYKAILEFAEKEGMVSSGQNLLAVESQ","proteinLength":"Fragment","predictedMolecularWeight":"60.3 kDa","actualMolecularWeight":null,"aminoAcidEnd":593,"aminoAcidStart":285,"nature":"Recombinant","expressionSystem":"Escherichia coli","accessionNumber":"P43378","tags":[{"tag":"GST","terminus":"N-Terminus"}]}]
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Properties and storage information

Shipped at conditions
Dry Ice
Appropriate short-term storage conditions
-80°C
Appropriate long-term storage conditions
-80°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
True
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

PTPN9 also known as protein tyrosine phosphatase non-receptor type 9 or PTP Meg2 functions as a protein tyrosine phosphatase that plays a role in dephosphorylating tyrosine residues on target proteins. It possesses a molecular mass of approximately 55 kDa. PTPN9 is expressed in various tissues including the liver placenta and pancreas and it is particularly relevant in blood cells like lymphocytes.
Biological function summary

This phosphatase regulates intracellular signaling related to cell proliferation differentiation and survival. PTPN9 participates in vesicular trafficking by binding to phosphatidylinositol lipids suggesting it might play a role in membrane-related processes. Though it does not usually form part of large stable complexes PTPN9 interacts dynamically with other proteins to regulate signal transduction.

Pathways

PTPN9 takes part in signaling cascades involved in immune responses and cellular growth processes. It interacts within the MAPK (Mitogen-Activated Protein Kinase) pathway which is critical for transmitting growth signals. Additionally PTPN9 relates to proteins like Ras and Raf within these pathways impacting how signals regulate cellular responses to external stimuli.

Research has linked PTPN9 to cancer and immune-related conditions. In cancers such as leukemia its altered function may contribute to unchecked cell proliferation. In immune disorders PTPN9 affects signaling processes linked with cytokine production and immune cell regulation. For instance associations with SHP-1 another phosphatase have shown relevance in these contexts influencing outcomes in pathological states.
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Specifications

Form

Liquid

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General info

Function

Protein-tyrosine phosphatase that could participate in the transfer of hydrophobic ligands or in functions of the Golgi apparatus.

Sequence similarities

Belongs to the protein-tyrosine phosphatase family. Non-receptor class 3 subfamily.

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Product protocols

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Target data

Protein-tyrosine phosphatase that could participate in the transfer of hydrophobic ligands or in functions of the Golgi apparatus.
See full target information Tyrosine-protein phosphatase non-receptor type 9
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