Recombinant human PTPRS protein
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Recombinant human PTPRS protein is a Human Fragment protein, in the 883 to 1501 aa range, expressed in Escherichia coli, with >70%, suitable for SDS-PAGE, FuncS.
View Alternative Names
Receptor-type tyrosine-protein phosphatase S, R-PTP-S, Receptor-type tyrosine-protein phosphatase sigma, R-PTP-sigma, PTPRS
- FuncS
Unknown
Functional Studies - Recombinant human PTPRS protein (AB90018)
Image showing specific activity of ab90018.
- SDS-PAGE
Unknown
SDS-PAGE - Recombinant human PTPRS protein (AB90018)
10% SDS-PAGE analysis of 7μg ab90018.
Reactivity data
Sequence info
Properties and storage information
Shipped at conditions
Appropriate short-term storage conditions
Appropriate long-term storage conditions
Supplementary information
This supplementary information is collated from multiple sources and compiled automatically.
Biological function summary
Protein Tyrosine Phosphatase Receptor Type S affects multiple cellular processes. It is not part of a large protein complex but interacts with cell adhesion molecules and other proteins involved in cell growth and differentiation. PTPRS contributes to neural development and repair by influencing axonal growth and guidance. It regulates synaptic architecture by modulating signaling pathways that affect neural plasticity and regeneration.
Pathways
PTPRS is involved in neural-related signaling cascades modulating cellular responses. One notable pathway where PTPRS plays a significant role is the Src pathway which regulates processes related to growth and differentiation. PTPRS interacts with proteins like Src kinase family members impacting their activity through dephosphorylation. This modulation of kinase activity directly influences cellular outcomes such as proliferation and cell motility.
Specifications
Form
Liquid
General info
Function
Cell surface receptor that binds to glycosaminoglycans, including chondroitin sulfate proteoglycans and heparan sulfate proteoglycan (PubMed : 21454754). Binding to chondroitin sulfate and heparan sulfate proteoglycans has opposite effects on PTPRS oligomerization and regulation of neurite outgrowth. Contributes to the inhibition of neurite and axonal outgrowth by chondroitin sulfate proteoglycans, also after nerve transection. Plays a role in stimulating neurite outgrowth in response to the heparan sulfate proteoglycan GPC2. Required for normal brain development, especially for normal development of the pituitary gland and the olfactory bulb. Functions as a tyrosine phosphatase (PubMed : 8524829). Mediates dephosphorylation of NTRK1, NTRK2 and NTRK3 (By similarity). Plays a role in down-regulation of signaling cascades that lead to the activation of Akt and MAP kinases (By similarity). Down-regulates TLR9-mediated activation of NF-kappa-B, as well as production of TNF, interferon alpha and interferon beta (PubMed : 26231120).
Sequence similarities
Belongs to the protein-tyrosine phosphatase family. Receptor class 2A subfamily.
Post-translational modifications
A cleavage occurs, separating the extracellular domain from the transmembrane segment. This process called 'ectodomain shedding' is thought to be involved in receptor desensitization, signal transduction and/or membrane localization (By similarity).
Target data
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Product promise
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