Recombinant Human PTRHD1 protein (His tag N-Terminus)

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

PTRHD1 also known as Peptidyl-tRNA hydrolase domain containing 1 is a protein with a molecular mass of approximately 26 kDa. It functions as part of the peptidyl-tRNA hydrolase family and is involved in ribosomal activity particularly in the release of tRNA from peptidyl-tRNA complexes. PTRHD1 expresses widely in human tissues with higher levels observed in the brain heart and muscle tissues. Its expression suggests a role in maintaining protein synthesis and cellular homeostasis.

Biological function summary

PTRHD1 is essential for normal cellular activities by enabling proper protein synthesis. It does not form part of a larger protein complex but interacts with ribosomal machinery to ensure tRNA recycling. This interaction highlights its participation in translation termination and recycling process within cells contributing to efficient protein production and avoiding the accumulation of toxic peptidyl-tRNA molecules.

Pathways

PTRHD1 plays a role in the translation and protein synthesis pathways. It connects with key proteins like ribosomal proteins and the elongation factor EF1A which facilitate the elongation and termination of protein chains during translation. Its activity ensures the fidelity and efficiency of these pathways impacting protein synthesis directly and therefore influencing the overall metabolic processes in cells.

PTRHD1 mutations associate with neurological disorders such as autosomal recessive intellectual disability and movement disorders. Its dysfunction leads to impaired neuronal activity and inadequate protein synthesis which can result in these neurological conditions. Additionally interactions with proteins like Parkin have been suggested hinting at its role in the pathology of Parkinson’s disease and reflecting its importance in maintaining neural function and cellular integrity.