Recombinant Human Putative 40S ribosomal protein-like (His tag)

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

The Putative 40S ribosomal protein-like sometimes referred to as RPL40-like functions as a structural component within the ribosomal subunit involved in translation. Its molecular weight is approximately 40 kDa. This protein localizes extensively in the cytoplasm specifically integrating into the small ribosomal subunit. Expression occurs widely across various tissues indicating a general role in protein synthesis.

Biological function summary

The Putative 40S ribosomal protein-like participates in the formation of the ribosome complex which is important for the translation of mRNA into proteins. As part of the ribosomal machinery this protein plays a role in ensuring the accuracy of translation and the efficient production of polypeptides. The interaction within the ribosome highlights its involvement in maintaining cellular protein homeostasis which is important for cell growth and function.

Pathways

The Putative 40S ribosomal protein-like integrates into the protein synthesis process contributing to the mTOR signaling pathway. The mTOR pathway regulates cell growth proliferation and survival and the protein's role links to its coordination in translation regulation. It also interacts with various translational factors such as eIF3 and eIF4 promoting efficient ribosomal initiation and elongation during protein synthesis.

Research links abnormal expression of ribosomal proteins including the Putative 40S ribosomal protein-like to certain cancers and hereditary ribosomopathies. Alterations in its expression or function may influence tumorigenesis due to disrupted protein synthesis and cell cycle control. Additionally RPL40-like can interact with other ribosomal proteins like RPL5 and RPL11 which are associated with Diamond-Blackfan anemia a disorder resulting from defective ribosome function.