Recombinant Human PVRIG/CD112R protein is a Human Full Length protein, in the 1 to 326 aa range, expressed in Cell free, with >=85% purity and suitable for SDS-PAGE.
Images
Key facts
- Purity
- >=85% SDS-PAGE
- Expression system
- Cell free
- Tags
- His tag N-Terminus
- Applications
- SDS-PAGE
- Biologically active
- No
Amino acid sequence
M R T E A Q V P A L Q P P E P G L E G A M G H R T L V L P W V L L T L C V T A G T P E V W V Q V R M E A T E L S S F T I R C G F L G S G S I S L V T V S W G G P N G A G G T T L A V L H P E R G I R Q W A P A R Q A R W E T Q S S I S L I L E G S G A S S P C A N T T F C C K F A S F P E G S W E A C G S L P P S S D P G L S A P P T P A P I L R A D L A G I L G V S G V L L F G C V Y L L H L L R R H K H R P A P R L Q P S R T S P Q A P R A R A W A P S Q A S Q A A L H V P Y A T I N T S C R P A T L D T A H P H G G P S W W A S L P T H A A H R P Q G P A A W A S T P I P A R G S F V S V E N G L Y A Q A G E R P P H T G P G L T L F P D P R G P R A M E G P L G V R
Reactivity data
| Application | Reactivity | Dilution info | Notes |
|---|---|---|---|
Application SDS-PAGE | Reactivity Reacts | Dilution info - | Notes - |
Target data
Function
Cell surface receptor for NECTIN2. May act as a coinhibitory receptor that suppresses T-cell receptor-mediated signals. Following interaction with NECTIN2, inhibits T-cell proliferation. Competes with CD226 for NECTIN2-binding.
Alternative names
C7orf15, PVRIG, Transmembrane protein PVRIG, CD112 receptor, Poliovirus receptor-related immunoglobulin domain-containing protein, CD112R
Recommended products
Recombinant Human PVRIG/CD112R protein is a Human Full Length protein, in the 1 to 326 aa range, expressed in Cell free, with >=85% purity and suitable for SDS-PAGE.
Key facts
- Purity
- >=85% SDS-PAGE
- Expression system
- Cell free
- Tags
- His tag N-Terminus
- Applications
- SDS-PAGE
- Biologically active
- No
- Accession
- Q6DKI7-1
- Animal free
- Yes
- Species
- Human
- Concentration
- Storage buffer
pH: 7.4 - 8
Constituents: 6% Trehalose, 0.87% Sodium chloride, 0.24% Tris, 0.05% dodecyl 2-(trimethylazaniumyl)ethyl phosphate
Sequence info
Amino acid sequence
- M R T E A Q V P A L Q P P E P G L E G A M G H R T L V L P W V L L T L C V T A G T P E V W V Q V R M E A T E L S S F T I R C G F L G S G S I S L V T V S W G G P N G A G G T T L A V L H P E R G I R Q W A P A R Q A R W E T Q S S I S L I L E G S G A S S P C A N T T F C C K F A S F P E G S W E A C G S L P P S S D P G L S A P P T P A P I L R A D L A G I L G V S G V L L F G C V Y L L H L L R R H K H R P A P R L Q P S R T S P Q A P R A R A W A P S Q A S Q A A L H V P Y A T I N T S C R P A T L D T A H P H G G P S W W A S L P T H A A H R P Q G P A A W A S T P I P A R G S F V S V E N G L Y A Q A G E R P P H T G P G L T L F P D P R G P R A M E G P L G V R
- Accession
- Q6DKI7
- Protein length
- Full Length
- Predicted molecular weight
- 50.3 kDa
- Amino acids
- 1 to 326
- Nature
- Recombinant
- Tags
- His tag N-Terminus
Specifications
- Form
- Lyophilized
General info
- Function
Cell surface receptor for NECTIN2. May act as a coinhibitory receptor that suppresses T-cell receptor-mediated signals. Following interaction with NECTIN2, inhibits T-cell proliferation. Competes with CD226 for NECTIN2-binding.
Storage
- Shipped at conditions
- Blue Ice
- Appropriate short-term storage duration
- 1-2 weeks
- Appropriate short-term storage conditions
- +4°C
- Appropriate long-term storage conditions
- -20°C
- Aliquoting information
- Upon delivery aliquot
- Storage information
- Avoid freeze / thaw cycle
Supplementary info
- This supplementary information is collated from multiple sources and compiled automatically.
- Activity summary
The PVRIG also known as CD112R is a cell surface receptor involved in immune responses. It has a molecular mass of approximately 38 kDa. Expressed mainly in immune cells including T cells and natural killer (NK) cells PVRIG binds with high affinity to its ligand CD112. This interaction modulates immune cell function by transmitting inhibitory signals that downregulate immune activation serving as a potential immune checkpoint.
- Biological function summary
PVRIG impacts immune cell behavior and is part of the inhibitory receptor family. Its primary role is to fine-tune the immune response by decreasing overactivation helping to maintain immune homeostasis. PVRIG interacts with other immune inhibitory receptors like TIGIT and PD-1 forming a complex network that suppresses overactive T cell responses. This process is important for preventing autoimmune reactions while allowing normal immune surveillance.
- Pathways
PVRIG participates in immune checkpoint pathways that influence T cell regulation. It plays a role in the immune checkpoint receptor pathway which is pivotal for controlling immune tolerance and immune-mediated inflammation. Within these pathways PVRIG works closely with other receptors like PD-1 forming a blockade that maintains the balance of immune activation and inhibition and participates in the immune synapse during antigen presentation.
- Associated diseases and disorders
PVRIG is relevant to cancer and autoimmune diseases. Its expression on T cells can be upregulated in tumor environments contributing to immune escape in cancers like melanoma. The PVRIG-CD112 interaction competes with other pathways such as TIGIT and CD112 further impacting tumor immune evasion. In autoimmune diseases PVRIG may prevent excessive immune responses linking it to conditions like rheumatoid arthritis where altered immune regulation occurs.
Product promise
We are dedicated to supporting your work with high quality reagents and we are here for you every step of the way should you need us.
In the unlikely event of one of our products not working as expected, you are covered by our product promise.
Full details and terms and conditions can be found here:
Terms & Conditions.
1 product image
SDS-PAGE - Recombinant Human PVRIG/CD112R protein (ab289749)
SDS-PAGE analysis of ab289749
Downloads
Product protocols
- Visit the general protocols
- Visit troubleshooting
Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.
For licensing inquiries, please contact partnerships@abcam.com