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AB224853

Recombinant Human PZP protein (His tag)

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Recombinant Human PZP protein (His tag) is a Human Fragment protein, in the 603 to 829 aa range, expressed in Escherichia coli, with >90%, suitable for SDS-PAGE.
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SDS-PAGE - Recombinant Human PZP protein (His tag) (AB224853)
  • SDS-PAGE

Supplier Data

SDS-PAGE - Recombinant Human PZP protein (His tag) (AB224853)

SDS-PAGE - Recombinant Human PZP (His tag) (ab224853) (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) analysis of ab224853 with 5% enrichment gel and 15% separation gel.

Key facts

Purity

>90% SDS-PAGE

Expression system

Escherichia coli

Tags

His tag N-Terminus

Applications

SDS-PAGE

applications

Biologically active

No

Accession

P20742-1

Animal free

No

Carrier free

No

Species

Human

Storage buffer

pH: 7.2 - 7.4 Constituents: Tris buffer, 50% Glycerol (glycerin, glycerine)

storage-buffer

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Complementary Products

Primary Antibodies

AB233166

Anti-PZP antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-PZP antibody (AB233166)

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Proteins & Peptides

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Recombinant Human C5a-R protein

SDS-PAGE - Recombinant Human C5a-R protein (AB289773)

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Proteins & Peptides

AB318252

Recombinant human IL36 gamma/IL-1F9 protein (His Tag)

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Proteins & Peptides

AB87669

Recombinant Human NKB protein (His tag N-Terminus)

SDS-PAGE - Recombinant Human NKB protein (His tag N-Terminus) (AB87669)

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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Product details

Previously labelled as Pregnancy zone protein.
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Sequence info

[{"linker":null,"sequence":"MKPEAELSVSSVYNLLTVKDLTNFPDNVDQQEEEQGHCPRPFFIHNGAIYVPLSSNEADIYSFLKGMGLKVFTNSKIRKPKSCSVIPSVSAGAVGQGYYGAGLGVVERPYVPQLGTYNVIPLNNEQSSGPVPETVRSYFPETWIWELVAVNSSGVAEVGVTVPDTITEWKAGAFCLSEDAGLGISSTASLRAFQPFFVELTMPYSVIRGEVFTLKATVLNYLPKCIRAEGIEQEKTFSSMTCASGANVSEQLSLKLPSNVVKESARASFSVLGDILGSAMQNIQNLLQMPYGCGEQNMVLFAPNIYVLNYLNETQQLTQEIKAKAVGYLITGYQRQLNYKHQDGSYSTFG","proteinLength":"Fragment","predictedMolecularWeight":"42.3 kDa","actualMolecularWeight":null,"aminoAcidEnd":829,"aminoAcidStart":603,"nature":"Recombinant","expressionSystem":"Escherichia coli","accessionNumber":"P20742","tags":[{"tag":"His","terminus":"N-Terminus"}]}]
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Properties and storage information

Form
Liquid
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
-20°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
False
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

PZP also known as Pregnancy Zone Protein is a critical glycoprotein with a molecular weight of approximately 360 kDa. It is mainly expressed in the liver but also found in the blood plasma particularly during pregnancy. PZP is similar in structure to alpha-2-macroglobulin and functions by inhibiting proteases. This protein binds and inactivates various proteinases showing its role in modulating enzymatic activity in the bloodstream.
Biological function summary

PZP contributes to immune response modulation during pregnancy by forming complexes with proteinases. These complexes prevent the degradation of other proteins helping to protect the fetus and maintain maternal immune tolerance. PZP exists as a tetramer in its active form allowing it to effectively trap and neutralize proteinases. Its expression levels rise significantly during pregnancy indicating its role in maternal adaptation.

Pathways

PZP is involved in the regulation of inflammation and the immune response. It participates in the acute phase response pathway which involves proteins like alpha-2-macroglobulin and C-reactive protein. By binding to various cytokines and growth factors PZP helps control inflammatory processes and cellular communication maintaining tissue homeostasis. These interactions show how PZP plays a role in protecting against excessive inflammation.

Researchers have linked PZP to conditions like Alzheimer's disease and cancer. In Alzheimer's PZP might interact with amyloid-beta peptides similar to alpha-2-macroglobulin hinting at a protective role against plaque formation. In cancer PZP's interaction with proteases suggests a role in tumor progression and metastasis. Understanding these links could help in developing therapeutic strategies targeting protease activity in these diseases.
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Product protocols

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Target data

Is able to inhibit all four classes of proteinases by a unique 'trapping' mechanism. This protein has a peptide stretch, called the 'bait region' which contains specific cleavage sites for different proteinases. When a proteinase cleaves the bait region, a conformational change is induced in the protein which traps the proteinase. The entrapped enzyme remains active against low molecular weight substrates (activity against high molecular weight substrates is greatly reduced). Following cleavage in the bait region a thioester bond is hydrolyzed and mediates the covalent binding of the protein to the proteinase.
See full target information PZP

Alternative Names

CPAMD6, PZP, Pregnancy zone protein, C3 and PZP-like alpha-2-macroglobulin domain-containing protein 6
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