Recombinant Human QDPR/DHPR protein is a Human Full Length protein, in the 1 to 244 aa range, expressed in Escherichia coli, with >90% purity and suitable for SDS-PAGE, MS.
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Key facts
- Purity
- >90% SDS-PAGE
- Expression system
- Escherichia coli
- Tags
- His tag N-Terminus
- Applications
- SDS-PAGE, MS
- Biologically active
- No
Reactivity data
| Application | Reactivity | Dilution info | Notes |
|---|---|---|---|
Application SDS-PAGE | Reactivity Reacts | Dilution info - | Notes - |
Application MS | Reactivity Reacts | Dilution info - | Notes - |
Target data
Function
Catalyzes the conversion of quinonoid dihydrobiopterin into tetrahydrobiopterin.
Alternative names
DHPR, SDR33C1, QDPR, Dihydropteridine reductase, HDHPR, Quinoid dihydropteridine reductase, Short chain dehydrogenase/reductase family 33C member 1
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Recombinant Human QDPR/DHPR protein is a Human Full Length protein, in the 1 to 244 aa range, expressed in Escherichia coli, with >90% purity and suitable for SDS-PAGE, MS.
Key facts
- Purity
- >90% SDS-PAGE
- Expression system
- Escherichia coli
- Tags
- His tag N-Terminus
- Applications
- SDS-PAGE, MS
- Biologically active
- No
- Accession
- P09417-1
- Animal free
- No
- Species
- Human
- Concentration
- Storage buffer
pH: 8.5
Constituents: 10% Glycerol (glycerin, glycerine), 0.32% Tris HCl, 0.04% (R*,R*)-1,4-Dimercaptobutan-2,3-diol
Sequence info
Amino acid sequence
- Accession
- P09417
- Protein length
- Full Length
- Predicted molecular weight
- 28.2 kDa
- Amino acids
- 1 to 244
- Nature
- Recombinant
- Tags
- His tag N-Terminus
Specifications
- Form
- Liquid
- Additional notes
ab113148 was purified using conventional chromatography techniques.
General info
- Function
Catalyzes the conversion of quinonoid dihydrobiopterin into tetrahydrobiopterin.
- Sequence similarities
Belongs to the short-chain dehydrogenases/reductases (SDR) family.
Storage
- Shipped at conditions
- Blue Ice
- Appropriate short-term storage conditions
- -20°C
- Appropriate long-term storage conditions
- -20°C
- Aliquoting information
- Upon delivery aliquot
- Storage information
- Avoid freeze / thaw cycle
Notes
Previously labelled as QDPR.
Supplementary info
- This supplementary information is collated from multiple sources and compiled automatically.
- Activity summary
QDPR also known as Quinoid Dihydropteridine Reductase or DHPR is an enzyme that plays an important role in tetrahydrobiopterin (BH4) regeneration. It has a molecular mass of approximately 25 kDa and is found in various tissues such as the liver and brain where it contributes to neurotransmitter synthesis and other physiological processes. The DHPR protein is encoded by the QDPR gene in humans and is highly conserved across species indicating its essential function.
- Biological function summary
QDPR catalyzes the reduction of quinonoid dihydrobiopterin (qBH2) to tetrahydrobiopterin maintaining BH4 homeostasis. This process supports neurotransmitter synthesis by replenishing BH4 a cofactor for aromatic amino acid hydroxylases. QDPR does not operate as part of a large multi-protein complex but has a significant role as a standalone enzyme that assists hydroxylating enzymes important for dopamine serotonin and nitric oxide production.
- Pathways
QDPR contributes to the biosynthesis of catecholamines and serotonin both essential neurotransmitter pathways. It supports phenylalanine hydroxylase tyrosine hydroxylase and tryptophan hydroxylase activities by sustaining BH4 levels. These pathways are integral to proper neurological function and are tightly regulated due to their dependence on QDPR's enzymatic activity. The function of QDPR aligns with the regulation of neurotransmitter metabolism working alongside other critical proteins in these pathways.
- Associated diseases and disorders
QDPR deficiency can result in hyperphenylalaninemia a condition characterized by elevated phenylalanine levels leading to cognitive impairments. This deficiency affects neurotransmitter synthesis linking it to neurological diseases such as depressive disorders. Additionally QDPR-related disruptions can implicate other proteins like phenylalanine hydroxylase showing how these metabolic pathways and their components are interwoven into broader physiological contexts.
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1 product image
SDS-PAGE - Recombinant Human QDPR/DHPR protein (ab113148)
15% SDS-PAGE showing ab113148 (3 μg) at approximately 28.2 kDa.
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