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AB187456

Recombinant Human QTRTD1 protein (His tag N-Terminus)

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Recombinant Human QTRTD1 protein (His tag N-Terminus) is a Human Full Length protein, in the 1 to 415 aa range, expressed in Escherichia coli, with >95%, suitable for SDS-PAGE, Mass Spec.

View Alternative Names

QTRTD1, QTRT2, Queuine tRNA-ribosyltransferase accessory subunit 2, Queuine tRNA-ribosyltransferase domain-containing protein 1

1 Images
SDS-PAGE - Recombinant Human QTRTD1 protein (His tag N-Terminus) (AB187456)
  • SDS-PAGE

Supplier Data

SDS-PAGE - Recombinant Human QTRTD1 protein (His tag N-Terminus) (AB187456)

15% SDS-PAGE analysis of ab187456 (3 μg)

Key facts

Purity

>95% SDS-PAGE

Expression system

Escherichia coli

Tags

His tag N-Terminus

Applications

Mass Spec, SDS-PAGE

applications

Biologically active

No

Accession

Q9H974

Animal free

No

Carrier free

No

Species

Human

Storage buffer

pH: 7.4 Constituents: PBS, 30% Glycerol (glycerin, glycerine), 0.03% (R*,R*)-1,4-Dimercaptobutan-2,3-diol, 0.03% EDTA, 0.002% PMSF

storage-buffer

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "Mass Spec": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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Sequence info

[{"sequence":"MGSSHHHHHHSSGLVPRGSHMGSMKLSLTKVVNGCRLGKIKNLGKTGDHTMDIPGCLLYTKTGSAPHLTHHTLHNIHGVPAMAQLTLSSLAEHHEVLTEYKEGVGKFIGMPESLLYCSLHDPVSPCPAGYVTNKSVSVWSVAGRVEMTVSKFMAIQKALQPDWFQCLSDGEVSCKEATSIKRVRKSVDRSLLFLDNCLRLQEESEVLQKSVIIGVIEGGDVMEERLRSARETAKRPVGGFLLDGFQGNPTTLEARLRLLSSVTAELPEDKPRLISGVSRPDEVLECIERGVDLFESFFPYQVTERGCALTFSFDYQPNPEETLLQQNGTQEEIKCMDQIKKIETTGCNQEITSFEINLKEKKYQEDFNPLVRGCSCYCCKNHTRAYIHHLLVTNELLAGVLLMMHNFEHYFGFFHYIREALKSDKLAQLKELIHRQAS","proteinLength":"Full Length","predictedMolecularWeight":"49.1 kDa","actualMolecularWeight":null,"aminoAcidEnd":415,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"Escherichia coli","accessionNumber":"Q9H974","tags":[{"tag":"His","terminus":"N-Terminus"}]}]
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Properties and storage information

Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
False
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

QTRTD1 also known as Queuine tRNA-ribosyltransferase domain containing 1 is a protein involved in a specialized post-transcriptional modification of tRNA molecules. This protein has a molecular mass of approximately 17 kDa. QTRTD1 is expressed in various tissues with notable levels in brain liver and heart indicating a broad role in cellular activity. Mechanically QTRTD1 contributes to the synthesis of queuosine a modified nucleoside found in certain tRNAs that influences translation fidelity.
Biological function summary

QTRTD1 catalyzes reactions important for the conversion of tRNAs to their queuosine-containing forms often functioning as part of a multiprotein complex. This modification plays an essential role in the maintenance of accurate protein synthesis under different physiological conditions. By modifying the anticodon loop of tRNA QTRTD1 helps modulate the efficiency and accuracy of codon recognition impacting protein translation in cells.

Pathways

QTRTD1 participates in the tRNA modification pathway that intersects with protein synthesis regulation. It interacts closely with queuine-inserting enzyme complex proteins such as QTRT1 to incorporate the queuosine base into the tRNA. This modification pathway contributes to translational control mechanisms which are fundamental in cellular stress responses and adapting to altered metabolic states.

QTRTD1 involvement in cancer and neurological disorders has received attention. Altered queuosine modification levels correlate with the progression of certain cancers potentially involving abnormal interactions with proteins like QTRT1 in tumorigenic processes. Additionally studies suggest a link between queuosine-deficient tRNA modification and neurodegenerative conditions implicating QTRTD1 in maintaining neural function. Understanding these connections may open pathways for therapeutic interventions targeting QTRTD1-related mechanisms.
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Specifications

Form

Liquid

Additional notes

ab187456 was purified using conventional chromatography.

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General info

Function

Non-catalytic subunit of the queuine tRNA-ribosyltransferase (TGT) that catalyzes the base-exchange of a guanine (G) residue with queuine (Q) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine).

Sequence similarities

Belongs to the queuine tRNA-ribosyltransferase family. QTRT2 subfamily.

Subcellular localisation

Mitochondrion outer membrane

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Product protocols

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Target data

Non-catalytic subunit of the queuine tRNA-ribosyltransferase (TGT) that catalyzes the base-exchange of a guanine (G) residue with queuine (Q) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine).
See full target information QTRT2
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