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AB309954

Recombinant Human Rab-6 protein

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Recombinant Human Rab-6 protein is a Human Full Length protein, in the 1 to 208 aa range, expressed in Escherichia coli, with >95%, <0.1 EU/mg endotoxin level, suitable for SDS-PAGE, Mass Spec, HPLC.

View Alternative Names

RAB6, RAB6A, Ras-related protein Rab-6A, Rab-6

3 Images
Mass Spectrometry - Recombinant Human Rab-6 protein (AB309954)
  • Mass Spec

Lab

Mass Spectrometry - Recombinant Human Rab-6 protein (AB309954)

Mass determination by ESI-TOF. Predicted MW is 23650.05 (+/- 10Da by ESI-TOF). Observed MW is 23650.09.

SDS-PAGE - Recombinant Human Rab-6 protein (AB309954)
  • SDS-PAGE

Lab

SDS-PAGE - Recombinant Human Rab-6 protein (AB309954)

SDS-PAGE analysis of ab309954

HPLC - Recombinant Human Rab-6 protein (AB309954)
  • HPLC

Lab

HPLC - Recombinant Human Rab-6 protein (AB309954)

HPLC analysis of ab309954

Key facts

Purity

>95% HPLC

Endotoxin level

<0.1 EU/mg

Expression system

Escherichia coli

Tags

Tag free

Applications

Mass Spec, HPLC, SDS-PAGE

applications

Biologically active

No

Accession

P20340

Animal free

Yes

Carrier free

No

Species

Human

Reconstitution

Lyophilized contents may appear as either a translucent film or a white powder. This variance does not affect the quality of the product. Store lyophilized form at room temperature. Reconstitute in phosphate buffered saline, aliquot and store at -80°C for 12 months or +4°C for 1 week. Avoid repeated freeze-thaw.

Storage buffer

pH: 7.4 Constituents: 10.26% Trehalose, 0.727% Dibasic monohydrogen potassium phosphate, 0.248% Potassium phosphate monobasic

storage-buffer

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "Mass Spec": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "HPLC": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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Sequence info

[{"sequence":"MSTGGDFGNPLRKFKLVFLGEQSVGKTSLITRFMYDSFDNTYQATIGIDFLSKTMYLEDRTVRLQLWDTAGQERFRSLIPSYIRDSTVAVVVYDITNVNSFQQTTKWIDDVRTERGSDVIIMLVGNKTDLADKRQVSIEEGERKAKELNVMFIETSAKAGYNVKQLFRRVAAALPGMESTQDRSREDMIDIKLEKPQEQPVSEGGCSC","proteinLength":"Full Length","predictedMolecularWeight":"23.7 kDa","actualMolecularWeight":"23.7 kDa","aminoAcidEnd":208,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"Escherichia coli","accessionNumber":"P20340","tags":[]}]
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Properties and storage information

Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
Ambient
Appropriate long-term storage conditions
Ambient
False
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Rab 6A also known as Ras-related protein Rab-6A is a member of the Rab family of small GTPases and has a molecular weight of approximately 24 kDa. This protein plays an essential role in intracellular transport mechanisms particularly overseeing the trafficking of proteins and lipids between the Golgi apparatus and the endoplasmic reticulum. Rab 6A is expressed in various tissues but is found predominantly in neuronal tissues where it has vital functions.
Biological function summary

This protein is involved in regulating membrane trafficking and maintains Golgi apparatus structure. Rab 6A engages with several other proteins to form complexes necessary for the vesicular transport processes. It aids in coordinating the interactions between transport vesicles and their target membranes directly impacting cellular homeostasis and protein export.

Pathways

Rab 6A operates significantly in the secretory pathway as well as the Golgi retrograde transport pathway. Within the secretory pathway it directly affects protein sorting and recycling. Additionally Rab 6A interacts with proteins such as Bicaudal-D and dynactin which link it to the recruitment and movement of vesicular cargo along the microtubules integrating it into the broader network of intracellular pathway regulation.

Rab 6A has connections with neurological conditions. Its dysfunction or misregulation can impact neurodegenerative diseases such as Alzheimer's disease by disrupting protein processing and transport. Rab 6A interacts with amyloid precursor protein-processing pathways emphasizing its role in disease pathways. Also Rab 6A is linked to disorders affecting the Golgi apparatus a critical site for protein post-translational modification and trafficking within cells.
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Specifications

Form

Lyophilized

Additional notes

SDS-PAGE >= 95%

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General info

Function

Regulator of COPI-independent retrograde transport from the Golgi apparatus towards the endoplasmic reticulum (ER) (PubMed : 25962623). Has a low GTPase activity (PubMed : 25962623). Recruits VPS13B to the Golgi membrane (PubMed : 25492866). Plays a role in neuron projection development (Probable).

Sequence similarities

Belongs to the small GTPase superfamily. Rab family.

Post-translational modifications

Prenylated.

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Product protocols

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Target data

Regulator of COPI-independent retrograde transport from the Golgi apparatus towards the endoplasmic reticulum (ER) (PubMed : 25962623). Has a low GTPase activity (PubMed : 25962623). Recruits VPS13B to the Golgi membrane (PubMed : 25492866). Plays a role in neuron projection development (Probable).
See full target information RAB6A
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