JavaScript is disabled in your browser. Please enable JavaScript to view this website.
AB132417

Recombinant Human RAB11FIP1 protein (GST tag N-Terminus)

Be the first to review this product! Submit a review

|

(0 Publication)

Recombinant Human RAB11FIP1 protein (GST tag N-Terminus) is a Human Fragment protein, in the 672 to 1283 aa range, expressed in Wheat germ, suitable for SDS-PAGE, ELISA, WB.

View Alternative Names

RCP, RAB11FIP1, Rab11 family-interacting protein 1, Rab11-FIP1, Rab-coupling protein

1 Images
SDS-PAGE - Recombinant Human RAB11FIP1 protein (AB132417)
  • SDS-PAGE

Unknown

SDS-PAGE - Recombinant Human RAB11FIP1 protein (AB132417)

12.5% SDS-PAGE analysis of ab132417, stained with Coomassie Blue.

Key facts

Expression system

Wheat germ

Tags

GST tag N-Terminus

Applications

ELISA, SDS-PAGE, WB

applications

Biologically active

No

Accession

Q6WKZ4

Animal free

No

Carrier free

No

Species

Human

Storage buffer

pH: 8 Constituents: 0.79% Tris HCl, 0.31% Glutathione

storage-buffer

style
left-column

Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "ELISA": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "WB": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
style
left-column
style
left-column

Sequence info

[{"sequence":"MGRTRETGTEKNTSSLELEESLPEQPETGRQEEELPRFPCKKQDYSPSSGEAQEVPFALSLSSDGAVSPVGELAAGGDRDLESQAGSLVESKARDAAEEVAPPLPMGASVPSIDSMMRKLEEMGLNLRKDQKKTKKRVSFSEQLFTEEAVAGAALLVEGHSSCPQELNPAWSVAGNASDGEPPESPHAEDSERESVTTPGPATCGAPASPADHLLLPSQEESFSEVPMSEASSAKDTPLFRMEGEDALVTQYQSKASDHEGLLSDPLSDLQLVSDFKSPIMADLNLSLPSIPEVASDDERIDQVEDDGDQVEDDGETAKSSTLDIGALSLGLVVPCPERGKGPSGEADRLVLGEGLCDFRLQAPQASVTAPSEQTTEFGIHKPHLGKSSSLDKQLPGPSGGEEEKPMGNGSPSPPPGTSLDNPVPSPSPSEIFPVTHSFPSSAHSDTHHTSTAESQKKATAEGSAGRVENFGKRKPLLQAWVSPSETHPVSAQPGAGTGSAKHRLHPVKPMNAMATKVANCSLGTATIISENLNNEVMMKKYSPSDPAFAYAQLTHDELIQLVLKQKETISKKEFQVRELEDYIDNLLVRVMEETPNILRIPTQVGKKAGKM","proteinLength":"Fragment","predictedMolecularWeight":"91.6 kDa","actualMolecularWeight":null,"aminoAcidEnd":1283,"aminoAcidStart":672,"nature":"Recombinant","expressionSystem":"Wheat germ","accessionNumber":"Q6WKZ4","tags":[{"tag":"GST","terminus":"N-Terminus"}]}]
style
left-column

Properties and storage information

Shipped at conditions
Dry Ice
Appropriate short-term storage conditions
-80°C
Appropriate long-term storage conditions
-80°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
False
style
left-column

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

RAB11FIP1 also known as Rab11 Family Interacting Protein 1 or pp75 is a protein that plays an important role in membrane trafficking. It acts as an effector molecule for Rab11 a small GTPase involved in the regulation of vesicle recycling. RAB11FIP1 has a mass of about 90 kDa and gets expressed in many tissues including brain liver and kidney. It contains regions critical for its interaction with Rab11 facilitating cargo sorting and transport within the endosomal recycling system.
Biological function summary

RAB11FIP1 is involved in several cellular functions related to endosomal transport and recycling processes. It is part of the recycling endosome complex where it helps in the sorting and delivery of cargo to the plasma membrane. The protein contributes to processes like insulin-stimulated glucose transporter 4 translocation and transferrin receptor recycling indicating its role in important cellular functions. It also associates with various other proteins to ensure efficient endocytic and exocytic pathway operations.

Pathways

RAB11FIP1 has significant roles in processes like the endocytic recycling pathway and the trans-Golgi network. Its interaction with Rab11 is part of the broader trafficking network regulating endocytic recycling critical for maintaining cell surface receptor levels. It is also linked with other proteins such as EHD1 known for their roles in endosomal transport highlighting its involvement in maintaining intracellular homeostasis and efficient transport of cellular material.

RAB11FIP1 contributes to conditions such as cancer and neurological disorders. Alterations in its function can disturb membrane trafficking pathways affecting processes like cell migration and proliferation linked to cancer development. Additionally its interactions with proteins such as E-cadherin important for cell adhesion further connect RAB11FIP1 to cancer progression. The protein is also implicated in neurological disorders due to its significant role in vesicle trafficking in neurons affecting synaptic function and potentially contributing to neurodegenerative diseases.
style
left-column

Specifications

Form

Liquid

style
left-column

General info

Function

A Rab11 effector protein involved in the endosomal recycling process. Also involved in controlling membrane trafficking along the phagocytic pathway and in phagocytosis.

Subcellular localisation

Recycling endosome

style
left-column

Product protocols

style
left-column

Target data

A Rab11 effector protein involved in the endosomal recycling process. Also involved in controlling membrane trafficking along the phagocytic pathway and in phagocytosis.
See full target information RAB11FIP1
style
left-column
style
left-column
style
right-column

Complementary Products

Primary Antibodies

AB154170

Anti-USP5 antibody [EPR10454]

RabMAb|Recombinant

Flow Cytometry (Intracellular) - Anti-USP5 antibody [EPR10454] (AB154170)

  • 0
  • 0
Primary Antibodies

AB67800

Anti-TRFP/MED20 antibody

Immunocytochemistry/ Immunofluorescence - Anti-TRFP/MED20 antibody (AB67800)

  • 0
  • 0
Primary Antibodies

AB251765

Anti-RAB11FIP1 antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-RAB11FIP1 antibody (AB251765)

  • 0
  • 0
Proteins & Peptides

AB95932

Recombinant Human eIF2A protein (His tag N-Terminus)

SDS-PAGE - Recombinant Human eIF2A protein (His tag N-Terminus) (AB95932)

  • 0
  • 0

Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.
For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com