Recombinant Human Rab15 protein is a Human Full Length protein, in the 2 to 212 aa range, expressed in Escherichia coli, with >90% purity and suitable for SDS-PAGE.
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| Application | Reactivity | Dilution info | Notes |
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Application SDS-PAGE | Reactivity Reacts | Dilution info - | Notes - |
May act in concert with RAB3A in regulating aspects of synaptic vesicle membrane flow within the nerve terminal.
Ras-related protein Rab-15, RAB15
Recombinant Human Rab15 protein is a Human Full Length protein, in the 2 to 212 aa range, expressed in Escherichia coli, with >90% purity and suitable for SDS-PAGE.
pH: 8
Constituents: 0.32% Tris HCl
This protein was expressed in E. coli as inclusion bodies, refolded using unique “temperature shift inclusion body refolding” technology and chromatographically purified.
May act in concert with RAB3A in regulating aspects of synaptic vesicle membrane flow within the nerve terminal.
Belongs to the small GTPase superfamily. Rab family.
Rab15 also known as Ras-related protein Rab-15 is a member of the Ras-related small GTPase family. This protein has a molecular mass of approximately 23 kDa. Rab15 localizes to endosomal membranes and plays an important role in regulating vesicle trafficking. It influences stages of endocytosis and recycling processes in cells. High expression of Rab15 is found in neural tissues especially in the brain which suggests its involvement in neuronal processes.
Rab15 regulates intracellular trafficking by controlling movement and fusion of vesicles. It acts as a molecular switch cycling between inactive GDP-bound and active GTP-bound states. Rab15 interacts with proteins that are part of the endosomal sorting complexes required for transport (ESCRT) to influence endosomal system organization. These interactions highlight Rab15’s role in coordinating proper cellular compartmentalization and signaling.
Rab15 affects processes within the endocytic pathway and is known to interact with the Rab family member Rab4. Rab15's involvement in the endosomal recycling pathway impacts the regulation of receptors including the transferrin receptor. This pathway is important for maintaining cellular homeostasis and exerting control over signal transduction in cells. Through these pathways Rab15 ensures efficient recycling of membrane receptors and other cellular components.
Aberrant Rab15 activity has been connected to neurological disorders and cancer. Rab15 dysregulation can lead to improper neural function and is linked to neurodegenerative diseases such as Alzheimer's disease. Additionally the interaction with other Rab proteins like Rab11 in cancer pathways suggests Rab15 contributes to tumor progression and metastasis. Understanding the interaction of Rab15 with these proteins could provide insights into therapeutic approaches for related diseases.
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