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AB216226

Recombinant Human Rab24 protein (Tagged)

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Recombinant Human Rab24 protein (Tagged) is a Human Full Length protein, in the 1 to 203 aa range, expressed in Escherichia coli, with >90%, suitable for SDS-PAGE.

View Alternative Names

Ras-related protein Rab-24, RAB24

Key facts

Purity

>90% SDS-PAGE

Expression system

Escherichia coli

Tags

Tag free

Applications

SDS-PAGE

applications

Biologically active

No

Accession

Q969Q5

Animal free

No

Carrier free

No

Species

Human

Storage buffer

pH: 8 Constituents: 0.32% Tris HCl

storage-buffer

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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Sequence info

[{"sequence":"MASMTGGQQMGRGHHHHHHENLYFQGGEFSGQRVDVKVVMLGKEYVGKTSLVERYVHDRFLVGPYQNTIGAAFVAKVMSVGDRTVTLGIWDTAGSERYEAMSRIYYRGAKAAIVCYDLTDSSSFERAKFWVKELRSLEEGCQIYLCGTKSDLLEEDRRRRRVDFHDVQDYADNIKAQLFETSSKTGQSVDELFQKVAEDYVSVAAFQVMTEDKGVDLGQKPNPYFYSCCHH","proteinLength":"Full Length","predictedMolecularWeight":"26.29 kDa","actualMolecularWeight":null,"aminoAcidEnd":203,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"Escherichia coli","accessionNumber":"Q969Q5","tags":[]}]
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Properties and storage information

Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-80°C
Storage information
Avoid freeze / thaw cycle
False
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Rab24 also known as Ras-related protein Rab-24 is a member of the Rab GTPase family. It participates in intracellular vesicle trafficking by functioning as a molecular switch that cycles between inactive GDP-bound and active GTP-bound states. Rab24 has a molecular weight of approximately 23 kDa. This protein is expressed in various tissues including the brain and testis suggesting it plays diverse roles in these areas.
Biological function summary

The Rab24 protein is essential in autophagy a cellular process that degrades and recycles components. It is known to participate in the formation of autophagic vacuoles a part of the greater autophagy pathway. Although not primarily part of a larger complex its interaction with other proteins supports the cell's homeostatic balance. Rab24 is less understood compared to other Rab proteins making it the focus of research for its unique properties.

Pathways

Involvement in autophagy and endocytic trafficking is established for Rab24. It plays a role in the regulation of intracellular membrane trafficking essential for cellular maintenance and nutrient supply. Rab24 associates with proteins such as LC3 during autophagic vacuole formation. These interactions position Rab24 as a significant player in pathways that maintain cellular health and response to stress.

Dysfunctional Rab24 activity has connections to neurodegenerative diseases and cancer. Abnormalities in autophagy linked to Rab24 mutations or dysregulation can contribute to conditions like Alzheimer's disease. Rab24's interplay with proteins like LC3 highlights its importance as these connections underline the potential for therapeutic targeting to address these disorders' underlying mechanisms.
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Specifications

Form

Liquid

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General info

Function

May be involved in autophagy-related processes.

Sequence similarities

Belongs to the small GTPase superfamily. Rab family.

Post-translational modifications

Isoprenylation is inefficient compared to other Rab family members.

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Product protocols

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Target data

May be involved in autophagy-related processes.
See full target information Ras-related protein Rab-24
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Complementary Products

Primary Antibodies

AB154824

Anti-Rab24 antibody [EPR9131]

RabMAb|Recombinant

Western blot - Anti-Rab24 antibody [EPR9131] (AB154824)

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