Recombinant Human RAB29 protein (GST tag N-Terminus)
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Recombinant Human RAB29 protein (GST tag N-Terminus) is a Human Full Length protein, in the 1 to 203 aa range, expressed in Wheat germ, suitable for ELISA, WB.
View Alternative Names
RAB7L1, RAB29, Ras-related protein Rab-29, Rab-7-like protein 1, Ras-related protein Rab-7L1
- SDS-PAGE
Unknown
SDS-PAGE - Recombinant Human RAB29 protein (GST tag N-Terminus) (AB160266)
ab160266 on a 12.5% SDS-PAGE stained with Coomassie Blue.
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Reactivity data
Sequence info
Properties and storage information
Shipped at conditions
Appropriate short-term storage conditions
Appropriate long-term storage conditions
Aliquoting information
Storage information
Supplementary information
This supplementary information is collated from multiple sources and compiled automatically.
Biological function summary
RAB29 plays an important role in ensuring the proper transport and sorting of proteins within cells. It associates with certain effector proteins to form complexes which facilitate movement between endosomes and other intracellular compartments. It coordinates with other RAB proteins to maintain cellular homeostasis and ensure effective intracellular transport. This coordination is significant for neural cells suggesting a specific importance in neurological environments.
Pathways
RAB29 engages in intracellular trafficking pathways that include the endocytic pathway and Golgi-lysosomal trafficking. In these pathways it cooperates closely with proteins like LRRK2 to regulate autophagy and the maintenance of the endosomal membrane system. Through these pathways it maintains cellular organelle distribution and affects lysosome functionality impacting overall cell health and metabolism.
Specifications
Form
Liquid
General info
Function
The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes (PubMed : 24788816). Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion (By similarity). RAB29 is essential for maintaining the integrity of the endosome-trans-Golgi network structure (By similarity). Together with LRRK2, plays a role in the retrograde trafficking pathway for recycling proteins, such as mannose 6 phosphate receptor (M6PR), between lysosomes and the Golgi apparatus in a retromer-dependent manner (PubMed : 24788816). Recruits LRRK2 to the Golgi complex and stimulates LRRK2 kinase activity (PubMed : 29212815, PubMed : 38127736). Stimulates phosphorylation of RAB10 'Thr-73' by LRRK2 (PubMed : 38127736). Regulates neuronal process morphology in the intact central nervous system (CNS) (By similarity). May play a role in the formation of typhoid toxin transport intermediates during Salmonella enterica serovar Typhi (S.typhi) epithelial cell infection (PubMed : 22042847).
Sequence similarities
Belongs to the small GTPase superfamily. Rab family.
Post-translational modifications
In case of Salmonella enterica serovar Typhimurium (S.typhimurium) infection, is proteolytically cleaved between Gly-41 and Val-42 by the GtgE viral protease encoded on the Gifsy-2 lysogen bacteriophage, which therefore prevents the recruitment of RAB29 to S.typhimurium-containing vacuoles. In contrast, no proteolytically cleavage is detected in S.typhi-infected cells (PubMed:22042847).
Subcellular localisation
Vacuole
Target data
Product promise
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