Recombinant Human RAB2B protein (His tag N-Terminus)
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Recombinant Human RAB2B protein (His tag N-Terminus) is a Human Full Length protein, in the 1 to 216 aa range, expressed in Escherichia coli, with >95%, suitable for SDS-PAGE, Mass Spec.
View Alternative Names
Ras-related protein Rab-2B, RAB2B
- SDS-PAGE
Supplier Data
SDS-PAGE - Recombinant Human RAB2B protein (His tag N-Terminus) (AB116205)
SDS-PAGE analysis of Recombinant Human RAB2B protein (ab116205), under reducing conditions. Proteins visualized by coomassie blue stain.
Lane 1 : Molecular Weight Standards
Lane 2 : 3 μg Recombinant Human RAB2B protein
Reactivity data
Sequence info
Properties and storage information
Shipped at conditions
Appropriate short-term storage duration
Appropriate short-term storage conditions
Appropriate long-term storage conditions
Aliquoting information
Storage information
Supplementary information
This supplementary information is collated from multiple sources and compiled automatically.
Biological function summary
Small GTPases like RAB2B act as molecular switches cycling between an inactive GDP-bound form and an active GTP-bound form. This mechanism allows RAB2B to regulate membrane trafficking within the cell. RAB2B is also part of a larger protein complex that includes other Rab GTPases and effector proteins coordinating the direction and delivery of transport vesicles. This regulation ensures the correct sorting and modification of proteins within cells which is important for cellular function and growth.
Pathways
Studies show RAB2B is integral to the COPI and COPII vesicular transport pathways which are vital for proper protein processing and degradation. These pathways involve a network of proteins including RAB1 and in particular RAB6 which highlight its role in mediating transport from the ER to the Golgi apparatus and in intra-Golgi traffic. These interactions emphasize the importance of RAB2B in maintaining cellular homeostasis and operation of secretory pathways efficiently.
Specifications
Form
Liquid
Additional notes
ab116205 was purified using conventional chromatography techniques.
General info
Function
The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between active GTP-bound and inactive GDP-bound states. In their active state, drive transport of vesicular carriers from donor organelles to acceptor organelles to regulate the membrane traffic that maintains organelle identity and morphology. Regulates the compacted morphology of the Golgi (Probable). Promotes cytosolic DNA-induced innate immune responses. Regulates IFN responses against DNA viruses by regulating the CGAS-STING signaling axis (By similarity). Together with RAB2A redundantly required for efficient autophagic flux (PubMed : 28483915).
Sequence similarities
Belongs to the small GTPase superfamily. Rab family.
Target data
Complementary Products
Product promise
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