Recombinant Human RAB33B protein

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

RAB33B also known as Ras-related protein Rab-33B is a small GTPase involved in intracellular vesicle trafficking. It has a molecular mass of about 25 kDa. RAB33B localizes mainly to the Golgi apparatus. It functions in regulating vesicle movement within the Golgi and between the Golgi and other organelles. This protein is widely expressed in various tissues suggesting its broad role in cellular processes.

Biological function summary

RAB33B interacts actively with other proteins like Golgins and SNAREs to mediate vesicle budding transport and fusion. It is part of a complex that influences Golgi structure and function playing a role in maintaining cellular homeostasis. Through its GTPase activity RAB33B helps manage the directionality and specificity of vesicle trafficking. This positions it as an important player in cellular logistics ensuring protein and lipid cargoes reach their destination effectively.

Pathways

The protein's function links it to the post-Golgi vesicular transport pathway. This pathway is critical for transporting proteins from the Golgi to their final destinations including the cell membrane. RAB33B also integrates with the GTPase cycle pathway working alongside other proteins like RAB1 and RAB6 which facilitate different stages of vesicle transport. These interactions ensure the smooth progression of Golgi-related pathways affecting various cellular functions.

RAB33B has been associated with Smith-McCort dysplasia a bone development disorder. Mutations affecting RAB33B disrupt normal Golgi function leading to defects in collagen secretion which impacts skeletal formation. Additionally its interactions with proteins like RAB1 in the context of disease have drawn attention to its potential role in viral infections as RAB proteins often play roles in the life cycle of certain viruses. Understanding these connections can provide insights into therapeutic targets and strategies.