Recombinant Human Rab34 protein (His tag N-Terminus)
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Recombinant Human Rab34 protein (His tag N-Terminus) is a Human Full Length protein, in the 1 to 259 aa range, expressed in Escherichia coli, with >90%, suitable for SDS-PAGE, Mass Spec.
View Alternative Names
RAB39, RAH, RAB34, Ras-related protein Rab-34, Ras-related protein Rab-39, Ras-related protein Rah
- SDS-PAGE
Unknown
SDS-PAGE - Recombinant Human Rab34 protein (His tag N-Terminus) (AB115717)
15% SDS-PAGE showing ab115717 (3μg).
Reactivity data
Sequence info
Properties and storage information
Shipped at conditions
Appropriate short-term storage duration
Appropriate short-term storage conditions
Appropriate long-term storage conditions
Aliquoting information
Storage information
Supplementary information
This supplementary information is collated from multiple sources and compiled automatically.
Biological function summary
Rab34 influences protein transport and lysosomal positioning. It does not function alone but participates as part of the cellular transport machinery. Rab34 regulates the movement of vesicles from the Golgi to the periphery of the cell thereby affecting secretion and cellular organization. Its action helps maintain correct cellular homeostasis and is key in cellular responses to environmental changes.
Pathways
The Rab34 protein is involved in the secretory and endocytic pathways. It works closely with other proteins such as Rab7 to coordinate the proper delivery and fusion of vesicles to their target membranes. Rab34 ensures efficient lysosomal distribution influencing processes like autophagy and endocytosis. Its role within these pathways emphasizes its importance in regulating cellular waste management and distribution of biomolecules.
Specifications
Form
Liquid
Additional notes
ab115717 was purified using conventional chromatography techniques.
General info
Function
Transport protein involved in the redistribution of lysosomes to the peri-Golgi region (PubMed : 27113757). Plays a role in the maturation of phagosomes that engulf pathogens, such as S.aureus and M.tuberculosis (PubMed : 21255211). Plays a role in the fusion of phagosomes with lysosomes (PubMed : 21255211). Involved in ciliogenesis (PubMed : 37384395). In particular, it is required for early steps of the intracellular cilium assembly pathway initiated by trafficking and docking of ciliary vesicles to the centrioles in the cytoplasm, followed by axoneme formation in the cytoplasm. After axoneme elongation, the centrioles migrate close to the cell surface so that ciliary vesicles can fuse with the plasma membrane to expose cilia to the extracellular space (By similarity). It seems dispensable for ciliogenesis via the extracellular pathway where cilium assembly begins after migration and docking of the centriole to the plasma membrane (By similarity). Acts also as a positive regulator of hedgehog signaling and regulates ciliary function (By similarity).
Sequence similarities
Belongs to the small GTPase superfamily. Rab family.
Target data
Complementary Products
Product promise
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