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AB160571

Recombinant Human RAB36 protein (GST tag N-Terminus)

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Recombinant Human RAB36 protein (GST tag N-Terminus) is a Human Full Length protein, in the 1 to 333 aa range, expressed in Wheat germ, suitable for ELISA, WB.

View Alternative Names

Ras-related protein Rab-36, RAB36

1 Images
SDS-PAGE - Recombinant Human RAB36 protein (GST tag N-Terminus) (AB160571)
  • SDS-PAGE

Unknown

SDS-PAGE - Recombinant Human RAB36 protein (GST tag N-Terminus) (AB160571)

ab160571 on a 12.5% SDS-PAGE stained with Coomassie Blue.

Key facts

Expression system

Wheat germ

Tags

GST tag N-Terminus

Applications

WB, ELISA

applications

Biologically active

No

Accession

O95755

Animal free

No

Carrier free

No

Species

Human

Storage buffer

pH: 8 Constituents: 0.79% Tris HCl, 0.31% Glutathione

storage-buffer

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "ELISA": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "WB": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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Sequence info

[{"sequence":"MVIAGASWMLGRAAASPTQTPPTTSTIRVARRSRVALVAMVIAAAGSGGPGRAEPQLSQPSLDCGRMRSSLTPLGPPVSRDRVIASFPKWYTPEACLQLREHFHGQVSAACQRRNTGTVGLKLSKVVVVGDLYVGKTSLIHRFCKNVFDRDYKATIGVDFEIERFEIAGIPYSLQIWDTAGQEKFKCIASAYYRGAQVIITAFDLTDVQTLEHTRQWLEDALRENEAGSCFIFLVGTKKDLLSGAACEQAEADAVHLAREMQAEYWSVSAKTGENVKAFFSRVAALAFEQSVLQDLERQSSARLQVGNGDLIQMEGSPPETQESKRPSSLGCC","proteinLength":"Full Length","predictedMolecularWeight":null,"actualMolecularWeight":null,"aminoAcidEnd":333,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"Wheat germ","accessionNumber":"O95755","tags":[{"tag":"GST","terminus":"N-Terminus"}]}]
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Properties and storage information

Shipped at conditions
Dry Ice
Appropriate short-term storage conditions
-80°C
Appropriate long-term storage conditions
-80°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
False
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

RAB36 is a member of the RAS oncogene family and functions mechanically as a small GTPase a protein that binds and hydrolyzes guanosine triphosphate (GTP). It is often abbreviated as member RAS oncogene family 36 in literature. This protein has a molecular mass of approximately 35 kDa. RAB36 is expressed in various tissues including the brain where it plays a significant role in intracellular signaling and transport processes.
Biological function summary

RAB36 regulates intracellular vesicle trafficking which is essential for proper cellular function. It does this by controlling vesicle movement along cytoskeletal tracks and facilitating the fusion of vesicles with their target membranes. RAB36 operates independently not forming part of any known complex but it might interact with other proteins that contribute to the same biological processes in the cell.

Pathways

RAB36 participates in the regulation of membrane trafficking pathways which are fundamental for cellular homeostasis and communication. These pathways indicate its association with proteins such as RAB7 and RAB9 both of which are also part of the RAB family and share roles in vesicular transport. RAB36 is particularly addressed in exocytic pathways influencing the delivery of proteins and lipids to the cell surface.

Alterations in RAB36 expression or function can link to disorders of intracellular trafficking like neurodegenerative diseases and cancer. Incorrect vesicle transport and fusion may contribute to the pathology of these conditions. Additionally proteins like RAB7 which is associated with RAB36 also relate to similar disorders highlighting the importance of proper regulation of the RAB family in disease prevention.
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Specifications

Form

Liquid

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General info

Function

The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion.

Sequence similarities

Belongs to the small GTPase superfamily. Rab family.

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Product protocols

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Target data

The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion.
See full target information RAB36
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Product promise

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