Recombinant Human RAB3IL1 protein is a Human Full Length protein, in the 1 to 382 aa range, expressed in Escherichia coli, with >90% purity and suitable for SDS-PAGE, MS.
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Key facts
- Purity
- >90% SDS-PAGE
- Expression system
- Escherichia coli
- Tags
- His tag N-Terminus
- Applications
- SDS-PAGE, MS
- Biologically active
- No
Amino acid sequence
M G S S H H H H H H S S G L V P R G S H M G S M W S G P P Q P D Q G L P P P L A A V P V P W K S T D P C Q G H R E S P G A L V E T S A G E E A Q G Q E G P A A A Q L D V L R L R S S S M E I R E K G S E F L K E E L H R A Q K E L K L K D E E C E R L S K V R E Q L E Q E L E E L T A S L F E E A H K M V R E A N M K Q A A S E K Q L K E A R G K I D M L Q A E V T A L K T L V I T S T P A S P N R E L H P Q L L S P T K A G P R K G H S R H K S T S S T L C P A V C P A A G H T L T P D R E G K E V D T I L F A E F Q A W R E S P T L D K T C P F L E R V Y R E D V G P C L D F T M Q E L S V L V R A A V E D N T L T I E P V A S Q T L P T V K V A E V D C S S T N T C A L S G L T R T C R H R I R L G D S K S H Y Y I S P S S R A R I T A V C N F F T Y I R Y I Q Q G L V R Q D A E P M F W E I M R L R K E M S L A K L G F F P Q E A
Reactivity data
| Application | Reactivity | Dilution info | Notes |
|---|---|---|---|
Application SDS-PAGE | Reactivity Reacts | Dilution info - | Notes - |
Application MS | Reactivity Reacts | Dilution info - | Notes - |
Target data
Function
Guanine nucleotide exchange factor (GEF) which may activate RAB3A, a GTPase that regulates synaptic vesicle exocytosis. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form. May also activate RAB8A and RAB8B.
Alternative names
Guanine nucleotide exchange factor for Rab-3A, Rab-3A-interacting-like protein 1, Rabin3-like 1, Rab3A-interacting-like protein 1, RAB3IL1
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Recombinant Human RAB3IL1 protein is a Human Full Length protein, in the 1 to 382 aa range, expressed in Escherichia coli, with >90% purity and suitable for SDS-PAGE, MS.
Key facts
- Purity
- >90% SDS-PAGE
- Expression system
- Escherichia coli
- Tags
- His tag N-Terminus
- Applications
- SDS-PAGE, MS
- Biologically active
- No
- Accession
- Q8TBN0-1
- Animal free
- No
- Species
- Human
- Concentration
- Storage buffer
pH: 7.4
Constituents: 50% Glycerol (glycerin, glycerine), 50% PBS
Sequence info
Amino acid sequence
- M G S S H H H H H H S S G L V P R G S H M G S M W S G P P Q P D Q G L P P P L A A V P V P W K S T D P C Q G H R E S P G A L V E T S A G E E A Q G Q E G P A A A Q L D V L R L R S S S M E I R E K G S E F L K E E L H R A Q K E L K L K D E E C E R L S K V R E Q L E Q E L E E L T A S L F E E A H K M V R E A N M K Q A A S E K Q L K E A R G K I D M L Q A E V T A L K T L V I T S T P A S P N R E L H P Q L L S P T K A G P R K G H S R H K S T S S T L C P A V C P A A G H T L T P D R E G K E V D T I L F A E F Q A W R E S P T L D K T C P F L E R V Y R E D V G P C L D F T M Q E L S V L V R A A V E D N T L T I E P V A S Q T L P T V K V A E V D C S S T N T C A L S G L T R T C R H R I R L G D S K S H Y Y I S P S S R A R I T A V C N F F T Y I R Y I Q Q G L V R Q D A E P M F W E I M R L R K E M S L A K L G F F P Q E A
- Accession
- Q8TBN0
- Protein length
- Full Length
- Predicted molecular weight
- 45 kDa
- Amino acids
- 1 to 382
- Nature
- Recombinant
- Tags
- His tag N-Terminus
Specifications
- Form
- Liquid
- Additional notes
ab187619 was purified using conventional chromatography techniques.
General info
- Function
Guanine nucleotide exchange factor (GEF) which may activate RAB3A, a GTPase that regulates synaptic vesicle exocytosis. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form. May also activate RAB8A and RAB8B.
- Sequence similarities
Belongs to the SEC2 family.
Storage
- Shipped at conditions
- Blue Ice
- Appropriate short-term storage duration
- 1-2 weeks
- Appropriate short-term storage conditions
- +4°C
- Appropriate long-term storage conditions
- -20°C
- Aliquoting information
- Upon delivery aliquot
- Storage information
- Avoid freeze / thaw cycle
Supplementary info
- This supplementary information is collated from multiple sources and compiled automatically.
- Activity summary
RAB3IL1 also known as RAB3A Interacting Protein Like 1 or GRAB functions mechanically as a guanine nucleotide exchange factor (GEF) that activates Rab proteins. It has a molecular weight of approximately 49 kDa. RAB3IL1 is expressed in various tissues including the brain kidney and the pancreas. It consists of domains that mediate interactions with other proteins facilitating its role in vesicle trafficking associated with exocytosis.
- Biological function summary
RAB3IL1 participates in the regulation of intracellular vesicle transport and secretion processes. It interacts with Rab3 proteins impacting synaptic vesicle cycle and neurotransmitter release. Although not forming a stable complex it temporarily associates with its target Rab proteins during activation. The protein influences cellular secretion linking vesicle transport to signal transduction pathways critical for cellular communication.
- Pathways
Vesicle-mediated trafficking and synaptic vesicle cycle are important to understanding RAB3IL1's role. It operates within pathways that regulate neurotransmitter release connecting with proteins like synaptotagmin I and UNC-18. These interactions enable accurate timing and regulation of vesicular transport and fusion highlighting RAB3IL1’s importance in neuronal communication.
- Associated diseases and disorders
RAB3IL1 has associations with neurological conditions and metabolic syndromes. It's linked to synaptic dysfunctions contributing to neurodegenerative disorders such as Alzheimer's disease. Furthermore its role in insulin secretion connects it to diabetes-related studies where it may interact with proteins like insulin receptor substrates influencing glucose homeostasis. These associations suggest that alterations in RAB3IL1 activity could impact the pathophysiology of these conditions.
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1 product image
SDS-PAGE - Recombinant Human RAB3IL1 protein (ab187619)
15% SDS-PAGE analysis of ab187619 (3 μg).
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