Recombinant Human RAB8B protein (denatured) (His tag N-Terminus)
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Recombinant Human RAB8B protein (denatured) (His tag N-Terminus) is a Human Full Length protein, in the 1 to 204 aa range, expressed in Escherichia coli, with >90%, suitable for SDS-PAGE.
View Alternative Names
Ras-related protein Rab-8B, RAB8B
- SDS-PAGE
Unknown
SDS-PAGE - Recombinant Human RAB8B protein (denatured) (His tag N-Terminus) (AB167867)
15% SDS-PAGE analysis of 3µg ab167867.
Reactivity data
Sequence info
Properties and storage information
Shipped at conditions
Appropriate short-term storage duration
Appropriate short-term storage conditions
Appropriate long-term storage conditions
Aliquoting information
Storage information
Supplementary information
This supplementary information is collated from multiple sources and compiled automatically.
Biological function summary
The small GTPase protein RAB8B assists in numerous cellular processes by influencing membrane trafficking. It facilitates the exocytic pathway and controls cargo delivery from the trans-Golgi network to the cell surface. RAB8B collaborates with effector proteins to form complexes that ensure correct vesicle fusion and membrane targeting. This protein is integral in maintaining cellular homeostasis and influencing processes like ciliogenesis essential for cell growth and signaling.
Pathways
Cellular processes involve RAB8B operating in the exocytic and endocytic pathways. Within these pathways RAB8B interacts closely with proteins like RAB11 and RAB5 which are important regulators of membrane transport. RAB8B ensures proper trafficking by regulating vesicle sorting and recycling which affects overall cellular functions. These interactions help coordinate receptor recycling and signal transduction pathways imperative for cellular communication and response.
Specifications
Form
Liquid
General info
Function
The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. That Rab may be involved in polarized vesicular trafficking and neurotransmitter release. May participate in cell junction dynamics in Sertoli cells (By similarity). May participate in the export of a subset of neosynthesized proteins through a Rab8-Rab10-Rab11-dependent endososomal export route (PubMed : 32344433).
Sequence similarities
Belongs to the small GTPase superfamily. Rab family.
Post-translational modifications
Phosphorylation of Thr-72 in the switch II region by LRRK2 prevents the association of RAB regulatory proteins, including CHM, CHML and RAB GDP dissociation inhibitors GDI1 and GDI2.
Target data
Complementary Products
Product promise
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