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AB161730

Recombinant Human RABGAP1 protein (GST tag N-Terminus)

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(1 Publication)

Recombinant Human RABGAP1 protein (GST tag N-Terminus) is a Human Full Length protein, in the 1 to 997 aa range, expressed in Wheat germ, suitable for ELISA, WB.

View Alternative Names

HSPC094, RABGAP1, Rab GTPase-activating protein 1, GAP and centrosome-associated protein, Rab6 GTPase-activating protein GAPCenA

1 Images
SDS-PAGE - Recombinant Human RABGAP1 protein (GST tag N-Terminus) (AB161730)
  • SDS-PAGE

Unknown

SDS-PAGE - Recombinant Human RABGAP1 protein (GST tag N-Terminus) (AB161730)

ab161730 on a 12.5% SDS-PAGE stained with Coomassie Blue.

Key facts

Expression system

Wheat germ

Tags

GST tag N-Terminus

Applications

ELISA, WB

applications

Biologically active

No

Accession

Q9Y3P9

Animal free

No

Carrier free

No

Species

Human

Storage buffer

pH: 8 Constituents: 0.79% Tris HCl, 0.31% Glutathione

storage-buffer

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Complementary Products

Primary Antibodies

AB153992

Anti-RABGAP1 antibody - C-terminal

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-RABGAP1 antibody - C-terminal (AB153992)

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Proteins & Peptides

AB159886

Recombinant Human ZP2 protein (GST tag N-Terminus)

SDS-PAGE - Recombinant Human ZP2 protein (GST tag N-Terminus) (AB159886)

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Proteins & Peptides

AB162402

Recombinant Human Zinc finger protein 691 (GST tag N-Terminus)

SDS-PAGE - Recombinant Human Zinc finger protein 691 (GST tag N-Terminus) (AB162402)

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  • 0
Proteins & Peptides

AB160339

Recombinant Human USP6 protein (GST tag N-Terminus)

SDS-PAGE - Recombinant Human USP6 protein (GST tag N-Terminus) (AB160339)

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  • 0
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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "ELISA": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "WB": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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Sequence info

[{"sequence":"MDDQPGEKELVKRSQLDGEGDGPLSNQLSASSTINPVPLVGLQKPEMSLPVKPGQGDSEASSPFTPVADEDSVVFSKLTYLGCASVNAPRSEVEALRMMSILRSQCQISLDVTLSVPNVSEGIVRLLDPQTNTEIANYPIYKILFCVRGHDGTPESDCFAFTESHYNAELFRIHVFRCEIQEAVSRILYSFATAFRRSAKQTPLSATAAPQTPDSDIFTFSVSLEIKEDDGKGYFSAVPKDKDRQCFKLRQGIDKKIVIYVQQTTNKELAIERCFGLLLSPGKDVRNSDMHLLDLESMGKSSDGKSYVITGSWNPKSPHFQVVNEETPKDKVLFMTTAVDLVITEVQEPVRFLLETKVRVCSPNERLFWPFSKRSTTENFFLKLKQIKQRERKNNTDTLYEVVCLESESERERRKTTASPSVRLPQSGSQSSVIPSPPEDDEEEDNDEPLLSGSGDVSKECAEKILETWGELLSKWHLNLNVRPKQLSSLVRNGVPEALRGEVWQLLAGCHNNDHLVEKYRILITKESPQDSAITRDINRTFPAHDYFKDTGGDGQDSLYKICKAYSVYDEEIGYCQGQSFLAAVLLLHMPEEQAFSVLVKIMFDYGLRELFKQNFEDLHCKFYQLERLMQEYIPDLYNHFLDISLEAHMYASQWFLTLFTAKFPLYMVFHIIDLLLCEGISVIFNVALGLLKTSKDDLLLTDFEGALKFFRVQLPKRYRSEENAKKLMELACNMKISQKKLKKYEKEYHTMREQQAQQEDPIERFERENRRLQEANMRLEQENDDLAHELVTSKIALRKDLDNAEEKADALNKELLMTKQKLIDAEEEKRRLEEESAQLKEMCRRELDKAESEIKKNSSIIGDYKQICSQLSERLEKQQTANKVEIEKIRQKVDDCERCREFFNKEGRVKGISSTKEVLDEDTDEEKETLKNQLREMELELAQTKLQLVEAECKIQDLEHHLGLALNEVQAAKKTWFNRTLSSIKTATGVQGKETC","proteinLength":"Full Length","predictedMolecularWeight":null,"actualMolecularWeight":null,"aminoAcidEnd":997,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"Wheat germ","accessionNumber":"Q9Y3P9","tags":[{"tag":"GST","terminus":"N-Terminus"}]}]
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Properties and storage information

Shipped at conditions
Dry Ice
Appropriate short-term storage conditions
-80°C
Appropriate long-term storage conditions
-80°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
False
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

RABGAP1 also known as Rab GTPase-activating protein 1 plays a significant role in regulating the activity of Rab proteins by promoting GTP hydrolysis to GDP. This regulation alters the Rab's affinity for membranes and their associated regulators and effectors. RABGAP1 has a mass of approximately 77 kDa and is functionally expressed in a range of tissues including those of the brain and pancreas indicating its importance in various cellular processes.
Biological function summary

RABGAP1 interacts with cellular components to modulate vesicular trafficking and membrane dynamics. It acts as a negative regulator in processes involving endocytosis and secretion by interfering in the Rab GTPase signaling cycle. This protein is not necessarily part of a larger multiprotein complex but works closely with members of the Rab family proteins. Through its activity RABGAP1 ensures accuracy in the transportation and sorting of cellular materials.

Pathways

RABGAP1 is involved in the regulation of the intracellular trafficking pathways particularly those linked with endocytosis and secretory routes. It functions in pathways associated with Rab GTPases influencing cellular processes such as vesicle budding and transport. This involvement places RABGAP1 in close functional association with proteins like Rab1 and Rab5 which are essential for membrane trafficking events and maintaining cellular organization.

Dysfunction of RABGAP1 is associated with alterations in cellular transport mechanisms which could contribute to diseases such as cancer and neurological disorders. Aberrant activity or expression levels of RABGAP1 may lead to the misregulation of protein trafficking therefore influencing cancer metastasis or neuronal pathologies. It may interact with other proteins related to these disorders such as Rab11 highlighting its role in the broader context of disease mechanisms.
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Specifications

Form

Liquid

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General info

Function

May act as a GTPase-activating protein of RAB6A. May play a role in microtubule nucleation by centrosome. May participate in a RAB6A-mediated pathway involved in the metaphase-anaphase transition.

Subcellular localisation

Cytoskeleton

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Product protocols

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Target data

May act as a GTPase-activating protein of RAB6A. May play a role in microtubule nucleation by centrosome. May participate in a RAB6A-mediated pathway involved in the metaphase-anaphase transition.
See full target information RABGAP1
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Cell discovery 4:1 PubMed29423269

2018

TUFT1 interacts with RABGAP1 and regulates mTORC1 signaling.

Applications

Unspecified application

Species

Unspecified reactive species

Natsumi Kawasaki,Kazunobu Isogaya,Shingo Dan,Takao Yamori,Hiroshi Takano,Ryoji Yao,Yasuyuki Morishita,Luna Taguchi,Masato Morikawa,Carl-Henrik Heldin,Tetsuo Noda,Shogo Ehata,Kohei Miyazono,Daizo Koinuma
View all publications
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Product promise

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