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AB160709

Recombinant Human RABGAP1L/HHL protein

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Recombinant Human RABGAP1L/HHL protein is a Human Fragment protein, in the 1 to 110 aa range, expressed in Wheat germ, suitable for ELISA, WB.

View Alternative Names

HHL, KIAA0471, RABGAP1L, Rab GTPase-activating protein 1-like

1 Images
SDS-PAGE - Recombinant Human RABGAP1L/HHL protein (AB160709)
  • SDS-PAGE

Unknown

SDS-PAGE - Recombinant Human RABGAP1L/HHL protein (AB160709)

ab160709 on a 12.5% SDS-PAGE stained with Coomassie Blue.

Key facts

Expression system

Wheat germ

Tags

GST tag N-Terminus

Applications

WB, ELISA

applications

Biologically active

No

Accession

Q5R372

Animal free

No

Carrier free

No

Species

Human

Storage buffer

pH: 8 Constituents: 0.79% Tris HCl, 0.31% Glutathione

storage-buffer

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "ELISA": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "WB": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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Product details

This product was previously labelled as RABGAP1L.
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Sequence info

[{"sequence":"MEVRASLQKVSGSSDSVATMNSEEFVLVPQYADDNSTKHEEKPQLKIVSNGDEQLEKAMEEILRDSEKRPSSLLVDCQSSSEISDHSFGDIPASQTNKPSLQLILDPSNT","proteinLength":"Fragment","predictedMolecularWeight":null,"actualMolecularWeight":null,"aminoAcidEnd":110,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"Wheat germ","accessionNumber":"Q5R372","tags":[{"tag":"GST","terminus":"N-Terminus"}]}]
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Properties and storage information

Shipped at conditions
Dry Ice
Appropriate short-term storage conditions
-80°C
Appropriate long-term storage conditions
-80°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
False
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

RABGAP1L also known as HHL is a GTPase-activating protein (GAP) that targets Rab GTPases which are important regulators of intracellular vesicle transport. The exact mass of the RABGAP1L protein is not well-documented but it is expressed in various tissues with significant presence in brain among others. This distribution suggests RABGAP1L's involvement in diverse cellular processes especially those requiring active vesicle trafficking and membrane dynamics.
Biological function summary

This protein acts as a regulatory molecule modulating the activity of Rab GTPases by accelerating the hydrolysis of GTP to GDP. This action helps switch the GTPases from an active to an inactive state which is vital for the spatial and temporal regulation of vesicular trafficking. RABGAP1L frequently associates with multiprotein complexes contributing to its regulatory functions in trafficking and signaling pathways.

Pathways

The protein plays a significant role in the endocytosis and exocytosis pathways that are vital for recycling membrane and macromolecules. RABGAP1L interacts with proteins like Rab11 in the endosomal recycling compartment which is essential for the efficient sorting and recycling of transmembrane proteins. These interactions highlight its involvement in the cellular management of vesicular transport and suggest its regulatory influence on several cellular processes.

RABGAP1L links to conditions such as neurological disorders and cancer where dysregulation of vesicular trafficking is a common factor. For instance its interaction with proteins involved in synaptic vesicle trafficking possibly associates it with certain neurodegenerative disorders. It also relates with oncogenic processes through its influence on the transport pathways mirroring dysfunctions seen in other regulatory proteins involved in cancer pathways.
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Specifications

Form

Liquid

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General info

Function

GTP-hydrolysis activating protein (GAP) for small GTPase RAB22A, converting active RAB22A-GTP to the inactive form RAB22A-GDP (PubMed : 16923123). Plays a role in endocytosis and intracellular protein transport. Recruited by ANK2 to phosphatidylinositol 3-phosphate (PI3P)-positive early endosomes, where it inactivates RAB22A, and promotes polarized trafficking to the leading edge of the migrating cells. Part of the ANK2/RABGAP1L complex which is required for the polarized recycling of fibronectin receptor ITGA5 ITGB1 to the plasma membrane that enables continuous directional cell migration (By similarity).

Subcellular localisation

Early endosome

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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

GTP-hydrolysis activating protein (GAP) for small GTPase RAB22A, converting active RAB22A-GTP to the inactive form RAB22A-GDP (PubMed : 16923123). Plays a role in endocytosis and intracellular protein transport. Recruited by ANK2 to phosphatidylinositol 3-phosphate (PI3P)-positive early endosomes, where it inactivates RAB22A, and promotes polarized trafficking to the leading edge of the migrating cells. Part of the ANK2/RABGAP1L complex which is required for the polarized recycling of fibronectin receptor ITGA5 ITGB1 to the plasma membrane that enables continuous directional cell migration (By similarity).
See full target information RABGAP1L
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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.
For full details, please see our Terms & Conditions
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Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

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