Recombinant Human RABIF protein

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

RABIF also known as Ras-related protein Rab guanine nucleotide exchange factor functions as a regulatory protein that facilitates the exchange of GDP for GTP on Rab proteins a process essential for their activation. The weight of RABIF is approximately 56 kDa. It finds expression in various tissues with significant presence in the pancreas and the brain. RABIF operates in intracellular trafficking by regulating dynamics of Rab GTPases which are important for vesicular transport mechanisms within cells.

Biological function summary

RABIF influences membrane trafficking processes by aiding the activation of Rab proteins which are part of a larger Rab family involved in vesicle movement between organelles. The protein functions as part of a larger complex contributing to the precise targeting and fusion of vesicles. This role is particularly important for maintaining cellular organization and homeostasis as it coordinates the movement of proteins and lipids within cells.

Pathways

Regulation by RABIF is essential in vesicular transport pathways such as endocytosis and exocytosis. Its activity is important for the actin cytoskeleton dynamics through interactions with proteins like Rab8 and Rab10 which affect cell shape and mobility. RABIF's functions align with pathways that manage intercellular signaling and membrane dynamics facilitating the transport essential for cellular responses to environmental changes.

Dysregulation of RABIF is linked with disorders like cancer and neurodegenerative diseases where vesicle transport and cell signaling play an important role. The protein interacts with factors like Rab3 which are significant for neurotransmitter release in neurons hinting at its implication in synaptic dysfunction present in conditions like Alzheimer's disease. Understanding RABIF’s function can provide insight into therapeutic targets for these complex diseases.