Recombinant Human RAET1E protein (Fc Chimera His Tag)
Be the first to review this product! Submit a review
|
(0 Publication)
Recombinant Human RAET1E protein (Fc Chimera His Tag) is a Human Fragment protein, in the 31 to 225 aa range, expressed in Baculovirus infected insect cells, with >85%, < 1 EU/µg endotoxin level, suitable for SDS-PAGE.
View Alternative Names
LETAL, N2DL4, ULBP4, UNQ1867/PRO4303, RAET1E, Retinoic acid early transcript 1E, Lymphocyte effector toxicity activation ligand, NKG2D ligand 4, RAE-1-like transcript 4, UL16-binding protein 4, N2DL-4, NKG2DL4
- SDS-PAGE
Supplier Data
SDS-PAGE - Recombinant Human RAET1E protein (Fc Chimera His Tag) (AB227416)
15% SDS-PAGE analysis of 3 μg ab227416.
MW 57-70 kDa (SDS-PAGE under reducing conditions).
Reactivity data
Product details
Sequence info
Properties and storage information
Shipped at conditions
Appropriate short-term storage duration
Appropriate short-term storage conditions
Appropriate long-term storage conditions
Aliquoting information
Storage information
Supplementary information
This supplementary information is collated from multiple sources and compiled automatically.
Biological function summary
RAET1E plays a role in immune surveillance. It is involved in the activation of NK cells when it binds to the NKG2D receptor. This interaction is part of the body's defense mechanism against transformed or infected cells. RAET1E operates in isolation rather than as part of a larger protein complex which allows it to independently initiate the immune response when detecting harmful cells.
Pathways
RAET1E functions within the innate immune response pathway. It works closely with the NKG2D signaling pathway which is important for the activation of cytotoxic activities in immune cells. RAET1E through its binding to NKG2D facilitates the destruction of malignant cells. This connection places RAET1E alongside other similar NKG2D ligands such as MIC and other ULBP family proteins which contribute to the activation of NK and T cells.
Specifications
Form
Liquid
Additional notes
Affinity purified
General info
Function
Binds and activates the KLRK1/NKG2D receptor, mediating natural killer cell cytotoxicity.
Sequence similarities
Belongs to the MHC class I family.
Target data
Complementary Products
![Western blot - Anti-RAET1E antibody [EPR17443] (AB200662)](https://content.abcam.com/products/images/raet1e-antibody-epr17443-ab200662--western-blot-img58924.jpg)
Product promise
Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.
For licensing inquiries, please contact partnerships@abcam.com