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Recombinant Human RAIDD protein is a Human Full Length protein, expressed in Escherichia coli, with >95% purity and suitable for SDS-PAGE.

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Images

SDS-PAGE - Recombinant Human RAIDD protein (AB78880), expandable thumbnail

Key facts

Purity

>95% SDS-PAGE

Expression system

Escherichia coli

Tags

Tag free

Applications

SDS-PAGE

Biologically active

No

Amino acid sequence

M G S S H H H H H H S S G L V P R G S H M E A R D K Q V L R S L R L E L G A E V L V E G L V L Q Y L Y Q E G I L T E N H I Q E I N A Q T T G L R K T M L M L D I L P S R G P K A F D T F L D S L Q E F P W V R E K L K K A R E E A M T D L P A G D R L T G I P S H I L N S S P S D R Q I N Q L A Q R L G P E W E P M V L S L G L S Q T D I Y R C K A N H P H N V Q S Q V V E A F I R W R Q R F G K Q A T F Q S L H N G L R A V E V D P S L L L H M L E

Reactivity data

Application

SDS-PAGE

Reactivity

Reacts

Dilution info

-

Notes

-

Associated Products

Select an associated product type

1 product for Alternative Product

Target data

Function

Adapter protein that associates with PIDD1 and the caspase CASP2 to form the PIDDosome, a complex that activates CASP2 and triggers apoptosis (PubMed:15073321, PubMed:16652156, PubMed:17159900, PubMed:17289572, PubMed:9044836). Also recruits CASP2 to the TNFR-1 signaling complex through its interaction with RIPK1 and TRADD and may play a role in the tumor necrosis factor-mediated signaling pathway (PubMed:8985253).

Alternative names

Recommended products

Recombinant Human RAIDD protein is a Human Full Length protein, expressed in Escherichia coli, with >95% purity and suitable for SDS-PAGE.

Key facts

Purity

>95% SDS-PAGE

Expression system

Escherichia coli

Applications

SDS-PAGE

Accession
P78560-1
Animal free

No

Species

Human

Concentration
Loading...
Storage buffer

pH: 8
Constituents: 20% Glycerol (glycerin, glycerine), 0.242% Tris

Sequence info

Amino acid sequence

M G S S H H H H H H S S G L V P R G S H M E A R D K Q V L R S L R L E L G A E V L V E G L V L Q Y L Y Q E G I L T E N H I Q E I N A Q T T G L R K T M L M L D I L P S R G P K A F D T F L D S L Q E F P W V R E K L K K A R E E A M T D L P A G D R L T G I P S H I L N S S P S D R Q I N Q L A Q R L G P E W E P M V L S L G L S Q T D I Y R C K A N H P H N V Q S Q V V E A F I R W R Q R F G K Q A T F Q S L H N G L R A V E V D P S L L L H M L E

Accession

P78560

Protein length

Full Length

Nature

Recombinant

Specifications

Form

Liquid

Additional notes

ab78880 is purified using conventional chromatography techniques.

General info

Function

Adapter protein that associates with PIDD1 and the caspase CASP2 to form the PIDDosome, a complex that activates CASP2 and triggers apoptosis (PubMed:15073321, PubMed:16652156, PubMed:17159900, PubMed:17289572, PubMed:9044836). Also recruits CASP2 to the TNFR-1 signaling complex through its interaction with RIPK1 and TRADD and may play a role in the tumor necrosis factor-mediated signaling pathway (PubMed:8985253).

Subcellular localisation

Nucleus

Storage

Shipped at conditions

Blue Ice

Appropriate short-term storage conditions

-20°C

Appropriate long-term storage conditions

-20°C

Aliquoting information

Upon delivery aliquot

Storage information

Avoid freeze / thaw cycle

Supplementary info

This supplementary information is collated from multiple sources and compiled automatically.

Activity summary

RAIDD also known as RIP-associated ICH-1/CED-3-homologous protein with a death domain (RIPDD) is an adaptor protein with a molecular mass of approximately 22 kDa. It is important for the formation of multiprotein signaling complexes. RAIDD contains a caspase recruitment domain and a death domain which facilitate its function in apoptotic pathways. It expresses in various tissues with a significant presence in immune and neural tissues where it has roles in regulating cell death and inflammation responses.

Biological function summary

RAIDD interacts closely with other proteins to regulate apoptosis. It forms part of the death-inducing signaling complex (DISC) a structure that recruits and activates initiator caspases like caspase-2. By acting as a bridge between receptor-interacting protein (RIP) and caspases RAIDD transmits signals that lead to programmed cell death. This regulation is central to cellular homeostasis and responses to damaging stimuli.

Pathways

RAIDD stands as a significant player in the apoptotic and inflammatory pathways. Apoptosis is well-documented where RAIDD serves as a connecting link to caspase-2 activation through the DISC. The second pathway of relevance is the TNF-receptor signaling pathway where RAIDD associates with RIP to influence downstream signaling events affecting expression of genes involved in immune response and cell cycle control.

Associated diseases and disorders

RAIDD's role in apoptosis and inflammation connects it to cancer and neurodegenerative diseases. In cancer RAIDD is involved in pathways that regulate tumor cell survival and death. Its interaction with proteins like caspase-2 can impact the fate of cancer cells potentially leading to abnormal cell proliferation or apoptosis resistance. In neurodegenerative conditions like Alzheimer's disease RAIDD's association with pro-inflammatory pathways and cell death mechanisms implicates it in neural cell injury and disease progression often in conjunction with RIP and caspases.

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1 product image

  • SDS-PAGE - Recombinant Human RAIDD protein (ab78880), expandable thumbnail

    SDS-PAGE - Recombinant Human RAIDD protein (ab78880)

    15% SDS-PAGE showing ab78880 at approximately 25kDa (3μg).

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Product protocols

For this product, it's our understanding that no specific protocols are required. You can:

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