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AB140554

Recombinant Human RAMP3 protein (His tag N-Terminus)

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Recombinant Human RAMP3 protein (His tag N-Terminus) is a Human Fragment protein, in the 24 to 118 aa range, expressed in Escherichia coli, with >90%, suitable for SDS-PAGE, Mass Spec.

View Alternative Names

Receptor activity-modifying protein 3, Calcitonin-receptor-like receptor activity-modifying protein 3, CRLR activity-modifying protein 3, RAMP3

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SDS-PAGE - Recombinant Human RAMP3 protein (His tag N-Terminus) (AB140554)
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Unknown

SDS-PAGE - Recombinant Human RAMP3 protein (His tag N-Terminus) (AB140554)

15% SDS-PAGE analysis of ab140554 (3μg)

Key facts

Purity

>90% SDS-PAGE

Expression system

Escherichia coli

Tags

His tag N-Terminus

Applications

SDS-PAGE, Mass Spec

applications

Biologically active

No

Accession

O60896

Animal free

No

Carrier free

No

Species

Human

Storage buffer

pH: 8 Constituents: 10% Glycerol (glycerin, glycerine), 0.58% Sodium chloride, 0.32% Tris HCl

storage-buffer

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "Mass Spec": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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Sequence info

[{"sequence":"MGSSHHHHHHSSGLVPRGSHMRAGGCNETGMLERLPLCGKAFADMMGKVDVWKWCNLSEFIVYYESFTNCTEMEANVVGCYWPNPLAQGFITGIHRQFFSNCTVDRVHLEDPPDEV","proteinLength":"Fragment","predictedMolecularWeight":"13 kDa","actualMolecularWeight":null,"aminoAcidEnd":118,"aminoAcidStart":24,"nature":"Recombinant","expressionSystem":"Escherichia coli","accessionNumber":"O60896","tags":[{"tag":"His","terminus":"N-Terminus"}]}]
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Properties and storage information

Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
False
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Specifications

Form

Liquid

Additional notes

ab140554 was purified using conventional chromatography.

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General info

Function

Accessory protein that interacts with and modulates the function of G-protein coupled receptors including calcitonin gene-related peptide type 1 receptor (CALCRL), calcitonin receptor (CALCR) and G-protein coupled estrogen receptor 1 (GPER1) (PubMed : 23674134, PubMed : 9620797). Required for the transport of CALCRL and GPER1 receptors to the plasma membrane (PubMed : 23674134, PubMed : 9620797). Plays a role in cardioprotection by reducing cardiac hypertrophy and perivascular fibrosis in a GPER1-dependent manner (PubMed : 23674134). Together with CALCRL, form a receptor complex for adrenomedullin/ADM and intermedin/ADM2 (PubMed : 32296767). Together with CALCR, act as a receptor complex for amylin/IAPP (PubMed : 35324283).

Sequence similarities

Belongs to the RAMP family.

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Product protocols

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Target data

Accessory protein that interacts with and modulates the function of G-protein coupled receptors including calcitonin gene-related peptide type 1 receptor (CALCRL), calcitonin receptor (CALCR) and G-protein coupled estrogen receptor 1 (GPER1) (PubMed : 23674134, PubMed : 9620797). Required for the transport of CALCRL and GPER1 receptors to the plasma membrane (PubMed : 23674134, PubMed : 9620797). Plays a role in cardioprotection by reducing cardiac hypertrophy and perivascular fibrosis in a GPER1-dependent manner (PubMed : 23674134). Together with CALCRL, form a receptor complex for adrenomedullin/ADM and intermedin/ADM2 (PubMed : 32296767). Together with CALCR, act as a receptor complex for amylin/IAPP (PubMed : 35324283).
See full target information Receptor activity-modifying protein 3
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