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AB215617

Recombinant Human RBP3/IRBP protein (His tag)

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Recombinant Human RBP3/IRBP protein (His tag) is a Human Fragment protein, in the 321 to 630 aa range, expressed in Escherichia coli, with >95%, < 1 EU/µg endotoxin level, suitable for SDS-PAGE.

View Alternative Names

Retinol-binding protein 3, Interphotoreceptor retinoid-binding protein, Interstitial retinol-binding protein, IRBP, RBP3

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SDS-PAGE - Recombinant Human RBP3/IRBP protein (His tag) (AB215617)
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Supplier Data

SDS-PAGE - Recombinant Human RBP3/IRBP protein (His tag) (AB215617)

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Key facts

Purity

>95% SDS-PAGE

Endotoxin level

< 1 EU/µg

Expression system

Escherichia coli

Tags

His tag N-Terminus

Applications

SDS-PAGE

applications

Biologically active

No

Accession

P10745

Animal free

No

Carrier free

No

Species

Human

Reconstitution

Reconstitute in water

Storage buffer

pH: 7.4 Constituents: PBS

storage-buffer

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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Product details

Previously labelled as RBP3.
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Sequence info

[{"sequence":"MNHKVHHHHHHMTLRSALPGVVHCLQEVLKDYYTLVDRVPTLLQHLASMDFSTVVSEEDLVTKLNAGLQAASEDPRLLVRAIGPTETPSWPAPDAAAEDSPGVAPELPEDEAIRQALVDSVFQVSVLPGNVGYLRFDSFADASVLGVLAPYVLRQVWEPLQDTEHLIMDLRHNPGGPSSAVPLLLSYFQGPEAGPVHLFTTYDRRTNITQEHFSHMELPGPRYSTQRGVYLLTSHRTATAAEEFAFLMQSLGWATLVGEITAGNLLHTRTVPLLDTPEGSLALTVPVLTFIDNHGEAWLGGGVVPDAIVLAEEALDKAQEVL","proteinLength":"Fragment","predictedMolecularWeight":"35 kDa","actualMolecularWeight":null,"aminoAcidEnd":630,"aminoAcidStart":321,"nature":"Recombinant","expressionSystem":"Escherichia coli","accessionNumber":"P10745","tags":[{"tag":"His","terminus":"N-Terminus"}]}]
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Properties and storage information

Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
-20°C
Appropriate long-term storage conditions
-20°C
Storage information
Avoid freeze / thaw cycle
False
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

The RBP3 protein also known as Interphotoreceptor Retinoid-Binding Protein (IRBP) plays a significant mechanical role in the eye. This protein is characterized by a mass of approximately 135 kDa and is primarily expressed in the retina and vitreous body. RBP3 is involved in the transport and protection of retinoids between the photoreceptor cells and the retinal pigment epithelium. It facilitates the movement of molecules necessary for the visual cycle ensuring efficient communication between different cellular components of the eye.
Biological function summary

RBP3 is integral in maintaining retinal health aiding the regeneration of visual pigments and the function of photosensitive cells. It does not appear to be part of a larger complex but operates independently within the extracellular space between the retina cells. The protein binds retinoids including retinol and retinaldehyde which are critical for converting light into visual signals. This function supports the overall visual transduction pathway in vertebrates.

Pathways

RBP3 is an important player in the visual cycle pathway maintaining normal vision by aiding in the synthesis and recycling of visual pigments. It works closely with proteins like opsin which is involved in the photoactivation required for vision. Furthermore RBP3 interacts within the retinoid cycle in the retina ensuring that retinoids are efficiently recycled and available for phototransduction.

RBP3 has connections with retinitis pigmentosa and age-related macular degeneration both of which are severe degenerative disorders of the retina. Mutations or deficiencies in RBP3 can disrupt retinoid transport leading to impaired vision or vision loss. This protein may be linked to other visual cycle proteins such as RPE65 which also play roles in the development of these diseases. Understanding RBP3's function and interaction with other proteins helps in developing therapeutic strategies for these retinal conditions.
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Specifications

Form

Lyophilized

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General info

Function

IRBP shuttles 11-cis and all trans retinoids between the retinol isomerase in the pigment epithelium and the visual pigments in the photoreceptor cells of the retina.

Sequence similarities

Belongs to the peptidase S41A family.

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Product protocols

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Target data

IRBP shuttles 11-cis and all trans retinoids between the retinol isomerase in the pigment epithelium and the visual pigments in the photoreceptor cells of the retina.
See full target information RBP3
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