Recombinant Human RBP5 protein

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Retinol-binding protein 5 (RBP5) also known as cellular retinol-binding protein 5 (CRBPV) is an intracellular protein that mechanically binds retinol and possibly retinoic acid. RBP5 has a molecular mass of approximately 15 kDa. This protein mainly expresses in the liver kidney and adipose tissue. It contains a lipocalin motif that facilitates the binding and transport of hydrophobic molecules like retinol.

Biological function summary

RBP5 influences processes related to retinoid metabolism and transport which is vital for maintaining cellular homeostasis. It functions as an integral part of the retinoid-binding protein family but does not form complexes with other proteins in its standard operation. RBP5 supports the storage and availability of retinoids for essential retinoid signaling pathways that affect cellular differentiation and proliferation.

Pathways

RBP5 warrants attention due to its role in retinol and cell signaling pathways as well as its significance in metabolic regulation. It closely relates to the retinoic acid signaling pathway in conjunction with proteins such as retinol-binding protein 4 (RBP4) and cellular retinoic acid binding proteins (CRABPs). These proteins collaboratively ensure the effective transport and metabolism of retinoids affecting gene expression and influencing various cellular functions.

RBP5 carries implications for metabolic diseases and certain cancers. Its altered expression associates with conditions like obesity and breast cancer. In particular deviations in RBP5 levels can influence the homeostasis and bioavailability of retinoids which impacts signaling pathways known to associate with these conditions. RBP5 also connects with RBP4 in the context of these disorders as both proteins play roles in modulating retinoid transport and metabolism further emphasizing their significance in disease pathology.