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AB104483

Recombinant Human RBP7 protein

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Recombinant Human RBP7 protein is a Human Full Length protein, in the 1 to 134 aa range, expressed in Escherichia coli, with >90%, suitable for SDS-PAGE, Mass Spec.

View Alternative Names

Retinoid-binding protein 7, Cellular retinoic acid-binding protein 4, Cellular retinoic acid-binding protein IV, CRABP4, CRBP4, CRABP-IV, RBP7

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SDS-PAGE - Recombinant Human RBP7 protein (AB104483)
  • SDS-PAGE

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SDS-PAGE - Recombinant Human RBP7 protein (AB104483)

15% SDS-PAGE analysis of ab104483 (3 μg).

Key facts

Purity

>90% SDS-PAGE

Expression system

Escherichia coli

Tags

His tag N-Terminus

Applications

Mass Spec, SDS-PAGE

applications

Biologically active

No

Accession

Q96R05

Animal free

No

Carrier free

No

Species

Human

Storage buffer

pH: 8 Constituents: 20% Glycerol (glycerin, glycerine), 1.16% Sodium chloride, 0.316% Tris HCl, 0.0308% (R*,R*)-1,4-Dimercaptobutan-2,3-diol

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "Mass Spec": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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Sequence info

[{"sequence":"MGSSHHHHHHSSGLVPRGSHMPADLSGTWTLLSSDNFEGYMLALGIDFATRKIAKLLKPQKVIEQNGDSFTIHTNSSLRNYFVKFKVGEEFDEDNRGLDNRKCKSLVIWDNDRLTCIQKGEKKNRGWTHWIEGDKLHLEMFCEGQVCKQTFQRA","proteinLength":"Full Length","predictedMolecularWeight":"17.6 kDa","actualMolecularWeight":null,"aminoAcidEnd":134,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"Escherichia coli","accessionNumber":"Q96R05","tags":[{"tag":"His","terminus":"N-Terminus"}]}]
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Properties and storage information

Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
-20°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
False
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Retinol Binding Protein 7 (RBP7) also known as CRBP4 belongs to the intracellular lipid-binding protein family. This protein has a molecular mass of approximately 15 kDa. RBP7 is expressed in various tissues including adipose tissue kidney and heart among others. It plays a role in shuttling retinoids intracellularly facilitating the transport and availability of retinol.
Biological function summary

The function of RBP7 involves maintaining retinoid homeostasis by regulating the storage and release of retinol within cells. It does not appear to be part of a larger protein complex. RBP7 contributes to cellular differentiation and proliferation influencing processes related to cell growth. Its roles are important in maintaining tissue health especially relating to vision and epithelial integrity.

Pathways

RBP7 is involved in the retinoic acid signaling pathway and contributes to lipid metabolism processes. Within these pathways it interacts indirectly with proteins such as retinaldehyde dehydrogenases that convert retinol into active forms. These pathways highlight the link RBP7 has with both metabolic and signaling functions showing its role in broader physiological contexts.

Alterations in RBP7 expression or function associate with conditions like obesity and type 2 diabetes. These alterations may affect retinoid pathways and consequently influence energy homeostasis and insulin sensitivity. Through its interactions in these pathways RBP7 shares connections with proteins such as peroxisome proliferator-activated receptor gamma (PPARγ) which also plays a role in metabolic regulation.
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Specifications

Form

Liquid

Additional notes

Purified using anion-exchange chromatography (DEAE sepharose resin) and gel-filtration chromatography (Sephacryl S-200) with 20mM Tris pH 7.5, 2mM EDTA.

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General info

Function

Intracellular transport of retinol.

Sequence similarities

Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.

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Product protocols

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Target data

Intracellular transport of retinol.
See full target information RBP7
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