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AB161411

Recombinant Human RBPJL protein

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Recombinant Human RBPJL protein is a Human Full Length protein, in the 1 to 517 aa range, expressed in Wheat germ, suitable for ELISA, WB.

View Alternative Names

RBPL, RBPSUHL, RBPJL, Recombining binding protein suppressor of hairless-like protein, Transcription factor RBP-L

1 Images
SDS-PAGE - Recombinant Human RBPJL protein (AB161411)
  • SDS-PAGE

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SDS-PAGE - Recombinant Human RBPJL protein (AB161411)

ab161411 on a 12.5% SDS-PAGE stained with Coomassie Blue.

Key facts

Expression system

Wheat germ

Tags

GST tag N-Terminus

Applications

WB, ELISA

applications

Biologically active

No

Accession

Q9UBG7

Animal free

No

Carrier free

No

Species

Human

Storage buffer

pH: 8 Constituents: 0.79% Tris HCl, 0.31% Glutathione

storage-buffer

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "ELISA": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "WB": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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Product details

This product was previously labelled as RBPSUHL.
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Sequence info

[{"sequence":"MDPAGAADPSVPPNPLTHLSLQDRSEMQLQSEADRRSLPGTWTRSSPEHTTILRGGVRRCLQQQCEQTVRILHAKVAQKSYGNEKRFFCPPPCVYLSGPGWRVKPGQDQAHQAGETGPTVCGYMGLDSASGSATETQKLNFEQQPDSREFGCAKTLYISDADKRKHFRLVLRLVLRGGRELGTFHSRLIKVISKPSQKKQSLKNTDLCISSGSKVSLFNRLRSQTVSTRYLSVEDGAFVASARQWAAFTLHLADGHSAQGDFPPREGYVRYGSLVQLVCTVTGITLPPMIIRKVAKQCALLDVDEPISQLHKCAFQFPGSPPGGGGTYLCLATEKVVQFQASPCPKEANRALLNDSSCWTIIGTESVEFSFSTSLACTLEPVTPVPLISTLELSGGGDVATLELHGENFHAGLKVWFGDVEAETMYRSPRSLVCVVPDVAAFCSDWRWLRAPITIPMSLVRADGLFYPSAFSFTYTPEYSVRPGHPGVPEPATDADALLESIHQEFTRTNFHLFIQT","proteinLength":"Full Length","predictedMolecularWeight":null,"actualMolecularWeight":null,"aminoAcidEnd":517,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"Wheat germ","accessionNumber":"Q9UBG7","tags":[{"tag":"GST","terminus":"N-Terminus"}]}]
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Properties and storage information

Shipped at conditions
Dry Ice
Appropriate short-term storage conditions
-80°C
Appropriate long-term storage conditions
-80°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
False
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

RBPJL also known as Recombination Signal Binding Protein for Ig κ J Region-like is a transcription factor with a molecular mass of around 60 kDa. It shares structural similarity with the RBPJ protein but differs in expression patterns. RBPJL is mainly expressed in acinar cells of the pancreas and in salivary glands. The protein functions mechanically by binding to specific DNA sequences influencing the transcription of certain genes important for cell differentiation and development in those tissues.
Biological function summary

RBPJL plays a role in the regulation of gene expression linked to the development and function of secretory cells. It acts as part of a transcription factor complex often interacting with other proteins like Notch pathway members. By modulating the transcription of target genes RBPJL helps maintain the proper structure and function of exocrine tissues supporting the production of digestive enzymes and other secretions.

Pathways

RBPJL functions within the Notch signaling pathway critical for cell fate determination and tissue homeostasis. The protein works closely with RBPJ a central mediator of the Notch pathway to co-regulate gene expression in exocrine tissues. Interaction with other signaling proteins like Hes1 further integrates RBPJL into a network that controls cellular differentiation and proliferation.

Alterations in RBPJL expression or function have been linked to pancreatic conditions such as pancreatitis and pancreatic cancer. The protein's relationship with RBPJ and the Notch signaling pathway suggests its impact on cell proliferation and apoptosis might influence disease progression. Dysregulated Notch signaling involving both RBPJL and related proteins may contribute to the pathogenesis of these diseases by affecting cellular homeostasis and promoting unchecked cell growth.
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Specifications

Form

Liquid

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General info

Function

Putative transcription factor, which cooperates with EBNA2 to activate transcription.

Sequence similarities

Belongs to the Su(H) family.

Subcellular localisation

Nucleus

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Product protocols

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Target data

Putative transcription factor, which cooperates with EBNA2 to activate transcription.
See full target information RBPJL
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