Recombinant Human RCL protein (His tag N-Terminus)
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Recombinant Human RCL protein (His tag N-Terminus) is a Human Full Length protein, in the 1 to 174 aa range, expressed in Escherichia coli, with >95%, suitable for SDS-PAGE, Mass Spec.
View Alternative Names
C6orf108, RCL, DNPH1, 5-hydroxymethyl-dUMP N-hydrolase, 2'-deoxynucleoside 5'-phosphate N-hydrolase 1, c-Myc-responsive protein RCL
- SDS-PAGE
Unknown
SDS-PAGE - Recombinant Human RCL protein (His tag N-Terminus) (AB100943)
15% SDS-PAGE showing ab100943 at approximately 21.2kDa (3µg).
Reactivity data
Sequence info
Properties and storage information
Shipped at conditions
Appropriate short-term storage conditions
Appropriate long-term storage conditions
Aliquoting information
Storage information
Supplementary information
This supplementary information is collated from multiple sources and compiled automatically.
Biological function summary
The reactive center loop operates by temporarily interacting with proteases to regulate their activities. It often finds itself as a component of a serpin-protease complex where it changes the enzymatic activity. This precise control allows proper regulation of proteolytic pathways that manage diverse physiological processes including inflammation and coagulation.
Pathways
Reactive center loops engage in the regulation of two main pathways: the coagulation cascade and the inflammatory response pathway. In these pathways RCLs work closely with proteins like thrombin and plasminogen to maintain a balance between enzyme activation and inhibition. Through these interactions RCLs help modulate the clot formation and dissolution as well as inflammatory response to injury.
Specifications
Form
Liquid
Additional notes
ab100943 was purified using conventional chromatography techniques.
General info
Function
Part of a nucleotide salvage pathway that eliminates epigenetically modified 5-hydroxymethyl-dCMP (hmdCMP) in a two-step process entailing deamination to cytotoxic 5-hydroxymethyl-dUMP (hmdUMP), followed by its hydrolysis into 5-hydroxymethyluracil (hmU) and 2-deoxy-D-ribose 5-phosphate (deoxyribosephosphate) (PubMed : 33833118). Catalyzes the second step in that pathway, the hydrolysis of the N-glycosidic bond in hmdUMP, degrading this cytotoxic nucleotide to avoid its genomic integration (PubMed : 33833118).
Sequence similarities
Belongs to the 2'-deoxynucleoside 5'-phosphate N-hydrolase 1 family.
Subcellular localisation
Nucleus
Target data
Complementary Products
Product promise
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