Recombinant Human RDHE2 protein

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

RDHE2 also known as Retinol Dehydrogenase 12 (RDH12) plays an important mechanical role in the metabolism of retinoids by catalyzing the oxidation and reduction of retinoids and other substrates. This protein has a molecular mass of approximately 35 kDa. RDHE2 expression can be found mainly in the retina but it also appears in other tissues like kidney and brain. The presence in these tissues emphasizes its role in local metabolic processes where it acts to maintain the balance of visual and non-visual retinoid-related activities.

Biological function summary

RDHE2 catalyzes the conversion of retinol to retinaldehyde an essential step in the visual cycle and non-visual cellular processes. RDHE2 does not typically function as part of a larger protein complex but it operates in coordination with other enzymes involved in retinoid metabolism. This activity holds significance for maintaining normal vision and cellular differentiation. Through its enzymatic activity RDHE2 manages the levels of retinoids important for both photoreceptor cell function in eyes and general cellular development in other tissues.

Pathways

RDHE2 is essential in the visual cycle and retinoic acid signaling pathway. These pathways play fundamental roles in converting all-trans-retinol to all-trans-retinal and then to retinoic acid which acts as a signaling molecule. Proteins such as RPE65 and LRAT work alongside RDHE2 in facilitating the isomerization and esterification of retinoids in the visual cycle emphasizing its importance in the retinoid metabolic pathway and its linkage to visual function.

Mutations or malfunctions in RDHE2 associate with retinal dystrophies including Leber Congenital Amaurosis (LCA) and retinitis pigmentosa. These conditions lead to the degeneration of retinal photoreceptor cells causing vision loss. RDHE2 relationships with proteins like CRALBP and RPE65 highlight its involvement in retinoid disorders accentuating its significance as a therapeutic target for retinal diseases. Understanding RDHE2 interactions and expression can aid in developing treatments for these visual impairments emphasizing its clinical value.