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AB276375

Recombinant Human REG1 protein (His tag)

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Recombinant Human REG1 protein (His tag) is a Human Full Length protein, in the 1 to 166 aa range, expressed in HEK 293 cells, with >97%, < 1 EU/µg endotoxin level, suitable for SDS-PAGE.

View Alternative Names

PSPS, PSPS1, REG, REG1A, Lithostathine-1-alpha, Islet cells regeneration factor, Islet of Langerhans regenerating protein, Pancreatic stone protein, Pancreatic thread protein, Regenerating islet-derived protein 1-alpha, Regenerating protein I alpha, ICRF, PSP, PTP, REG-1-alpha

1 Images
SDS-PAGE - Recombinant Human REG1 protein (His tag) (AB276375)
  • SDS-PAGE

Supplier Data

SDS-PAGE - Recombinant Human REG1 protein (His tag) (AB276375)

SDS-PAGE analysis of ab276375

Key facts

Purity

>97% SDS-PAGE

Endotoxin level

< 1 EU/µg

Expression system

HEK 293 cells

Tags

His tag C-Terminus

Applications

SDS-PAGE

applications

Biologically active

No

Accession

P05451

Animal free

No

Carrier free

No

Species

Human

Storage buffer

pH: 7.4 Constituents: 100% PBS

storage-buffer

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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Sequence info

[{"sequence":"MAQTSSYFMLISCLMFLSQSQGQEAQTELPQARISCPEGTNAYRSYCYYFNEDRETWVDADLYCQNMNSGNLVSVLTQAEGAFVASLIKESGTDDFNVWIGLHDPKKNRRWHWSSGSLVSYKSWGIGAPSSVNPGYCVSLTSSTGFQKWKDVPCEDKFSFVCKFKN","proteinLength":"Full Length","predictedMolecularWeight":"17.7 kDa","actualMolecularWeight":null,"aminoAcidEnd":166,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"HEK 293 cells","accessionNumber":"P05451","tags":[{"tag":"His","terminus":"C-Terminus"}]}]
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Properties and storage information

Shipped at conditions
Ambient - Can Ship with Ice
Appropriate short-term storage conditions
-20°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
False
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

The Regenerating Gene 1 (REG1) also known as Reg1 or pancreatitis-associated protein 1 (PAP1) is a small protein with a molecular mass of approximately 16 kDa. It functions as a C-type lectin and binds carbohydrates affecting diverse biological activities.
Biological function summary

REG1 interacts with numerous cellular processes including cell proliferation survival and differentiation. It is not part of a complex but it displays localization primarily in the pancreas influencing exocrine pancreatic secretion. It also appears in other tissues such as the small intestine. Important in tissue regeneration and protection REG1 helps in repairing damage especially in the context of injury or stress.

Pathways

REG1 influences cell growth and apoptosis regulation. It participates in pathways involving pancreatic acinar cell growth like those modulated by cytokines and inflammatory mediators. REG1 interacts with proteins such as REG3 and they both play essential roles in maintaining cellular homeostasis upon injury particularly in digestive organs.

REG1 has associations with pancreatic inflammations like chronic pancreatitis and diabetes mellitus. Its expression becomes altered in these conditions which suggests a role in pathological processes. Interaction of REG1 with inflammatory cytokines links this protein to disease pathogenesis especially with proteins like IL-6 in the context of chronic inflammation and metabolic dysregulation.
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Specifications

Form

Lyophilized

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General info

Function

Might act as an inhibitor of spontaneous calcium carbonate precipitation. May be associated with neuronal sprouting in brain, and with brain and pancreas regeneration.

Post-translational modifications

The composition of the O-linked carbohydrate on Thr-27 is complex and varied. In the crystallographic structure, the attached sugar appears to be N-acetylglucosamine, typical of an intracellular protein, rather than N-acetylgalactosamine.

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Product protocols

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Target data

Might act as an inhibitor of spontaneous calcium carbonate precipitation. May be associated with neuronal sprouting in brain, and with brain and pancreas regeneration.
See full target information REG1A
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