Recombinant Human REG3G protein
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Recombinant Human REG3G protein is a Human Full Length protein, in the 27 to 175 aa range, expressed in HEK 293 cells, with >95%, < 1 EU/µg endotoxin level, suitable for SDS-PAGE, HPLC.
View Alternative Names
PAP1B, UNQ429/PRO162, REG3G, Regenerating islet-derived protein 3-gamma, REG-3-gamma, Pancreatitis-associated protein 1B, Pancreatitis-associated protein IB, Regenerating islet-derived protein III-gamma, PAP-1B, PAP IB, REG III, Reg III-gamma
Reactivity data
Sequence info
Properties and storage information
Shipped at conditions
Appropriate short-term storage duration
Appropriate short-term storage conditions
Appropriate long-term storage conditions
Storage information
Supplementary information
This supplementary information is collated from multiple sources and compiled automatically.
Biological function summary
REG3G plays a role in innate immune responses by maintaining homeostasis in the intestinal mucosa. It is not reported as part of a larger protein complex. REG3G helps modulate the gut microbiota and provides protection against pathogenic bacteria. The ability to control bacterial populations in the gut and prevent invasion highlights the protein’s role in the body's defense mechanisms.
Pathways
REG3G participates in the antimicrobial peptide pathway contributing to mucosal immunity. This pathway plays an important role in the gastrointestinal tract where it prevents infection by pathogens. REG3G is related to other antimicrobial peptides such as REG3A and defensins which collectively enhance the mucosal barrier and protect against microbial invasion.
Specifications
Form
Lyophilized
Additional notes
Determined by SEC-HPLC and reducing SDS-PAGE.
General info
Function
Bactericidal C-type lectin which acts exclusively against Gram-positive bacteria and mediates bacterial killing by binding to surface-exposed carbohydrate moieties of peptidoglycan. Restricts bacterial colonization of the intestinal epithelial surface and consequently limits activation of adaptive immune responses by the microbiota.. Acts as a hormone in response to different stimuli like anti-inflammatory signals, such as IL17A, or gut microbiome. Is secreted by different cell types to activate its receptor EXTL3 and induce cell specific signaling pathways. Induced by IL17A in keratinocytes, regulates keratinocyte proliferation and differentiation after skin injury. In parallel, inhibits skin inflammation through the inhibition of inflammatory cytokines such as IL6 and TNF. Induced by IL22 in lung epithelial cells, inhibits cytokine production and regulates allergic airway inflammation. Induced in small intestine by inulin-enriched diet and Lactobacillus gasseri enriched microbiome, plays a role in the improvement of gut barrier function, the regulation of energy balance and glucose levels. Modulates microbiota composition in duodenal contents. Produced by nociceptor in response to endotoxins, prevents endotoxic death by targeting kynurenine pathway in microglia.. Regenerating islet-derived protein 3-gamma 16.5 kDa form. Has bacteriostatic activity.. Regenerating islet-derived protein 3-gamma 15 kDa form. Has bactericidal activity against L.monocytogenes and methicillin-resistant S.aureus.
Post-translational modifications
Proteolytic processing by trypsin removes an inhibitory N-terminal propeptide and is essential for peptidoglycan binding and antibacterial activity.
Target data
Complementary Products
Product promise
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