Recombinant Human Renin Receptor protein
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Recombinant Human Renin Receptor protein is a Human Full Length protein, in the 1 to 350 aa range, expressed in Wheat germ, suitable for ELISA, WB.
View Alternative Names
ATP6IP2, CAPER, ELDF10, HT028, MSTP009, PSEC0072, ATP6AP2, Renin receptor, ATPase H(+)-transporting lysosomal accessory protein 2, ATPase H(+)-transporting lysosomal-interacting protein 2, ER-localized type I transmembrane adapter, Embryonic liver differentiation factor 10, N14F, Renin/prorenin receptor, Vacuolar ATP synthase membrane sector-associated protein M8-9, ATP6M8-9, V-ATPase M8.9 subunit
- SDS-PAGE
Unknown
SDS-PAGE - Recombinant Human Renin Receptor protein (AB153053)
ab153053 on a 12.5% SDS-PAGE stained with Coomassie Blue.
Reactivity data
Product details
Sequence info
Properties and storage information
Shipped at conditions
Appropriate short-term storage conditions
Appropriate long-term storage conditions
Aliquoting information
Storage information
Supplementary information
This supplementary information is collated from multiple sources and compiled automatically.
Biological function summary
The Renin Receptor participates in maintaining homeostasis within the renin-angiotensin-aldosterone system. It potentially forms part of a larger receptor complex by interacting with other pathway components. By modulating the activity of renin and prorenin it enhances blood pressure regulation and fluid balance contributing to cardiovascular function and cellular ion homeostasis. Its involvement extends to promoting cell signaling events related to growth development and metabolism through the MAPK pathway.
Pathways
The Renin Receptor integrates into the renin-angiotensin system and the Wnt signaling pathway. In the renin-angiotensin system the receptor interacts with proteins such as angiotensin-converting enzyme (ACE) and angiotensin receptors playing an important role in blood pressure and electrolyte balance. Its engagement in the Wnt pathway suggests a role in development and cellular proliferation highlighting its interaction with proteins involved in cellular communication and embryonic development.
Specifications
Form
Liquid
General info
Function
Multifunctional protein which functions as a renin, prorenin cellular receptor and is involved in the assembly of the lysosomal proton-transporting V-type ATPase (V-ATPase) and the acidification of the endo-lysosomal system (PubMed : 12045255, PubMed : 29127204, PubMed : 30374053, PubMed : 32276428). May mediate renin-dependent cellular responses by activating ERK1 and ERK2 (PubMed : 12045255). By increasing the catalytic efficiency of renin in AGT/angiotensinogen conversion to angiotensin I, may also play a role in the renin-angiotensin system (RAS) (PubMed : 12045255). Through its function in V-type ATPase (v-ATPase) assembly and acidification of the lysosome it regulates protein degradation and may control different signaling pathways important for proper brain development, synapse morphology and synaptic transmission (By similarity).
Post-translational modifications
Phosphorylated.. Proteolytically cleaved by a furin-like convertase in the trans-Golgi network to generate N- and C-terminal fragments.
Subcellular localisation
Lysosome membrane
Target data
Complementary Products
Product promise
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