Recombinant Human REV1 protein (denatured)
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Recombinant Human REV1 protein (denatured) is a Human Fragment protein, in the 51 to 256 aa range, expressed in Escherichia coli, with >85%, suitable for SDS-PAGE.
View Alternative Names
REV1L, REV1, DNA repair protein REV1, Alpha integrin-binding protein 80, Rev1-like terminal deoxycytidyl transferase, AIBP80
- SDS-PAGE
Supplier Data
SDS-PAGE - Recombinant Human REV1 protein (denatured) (AB180340)
15% SDS-PAGE analysis of ab180340 (3 μg).
Reactivity data
Sequence info
Properties and storage information
Shipped at conditions
Appropriate short-term storage duration
Appropriate short-term storage conditions
Appropriate long-term storage conditions
Aliquoting information
Storage information
Supplementary information
This supplementary information is collated from multiple sources and compiled automatically.
Biological function summary
REV1 operates within the context of DNA repair and a larger polymerase zeta complex working closely with other translesion DNA polymerases. REV1 interacts with other translesion synthesis proteins like POLH POLL and POLK to orchestrate the bypass of different types of DNA damage. These interactions enable REV1 to play a role in cellular responses to DNA damage and contribute to maintaining genome integrity.
Pathways
REV1 integrates into the DNA damage response and translesion synthesis pathways. In these pathways REV1 coordinates with REV3L and REV7 forming part of the polymerase zeta complex to process lesions bypass that regular DNA polymerases cannot handle. Significantly it associates with the Fanconi anemia pathway affecting DNA repair mechanisms under stress. These collaborations help manage replication stress and stabilize cellular division.
Specifications
Form
Liquid
General info
Function
Deoxycytidyl transferase involved in DNA repair. Transfers a dCMP residue from dCTP to the 3'-end of a DNA primer in a template-dependent reaction. May assist in the first step in the bypass of abasic lesions by the insertion of a nucleotide opposite the lesion. Required for normal induction of mutations by physical and chemical agents.
Sequence similarities
Belongs to the DNA polymerase type-Y family.
Subcellular localisation
Nucleus
Target data
Complementary Products
Product promise
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