Recombinant Human REXO1 protein is a Human Fragment protein, in the 1060 to 1221 aa range, expressed in Escherichia coli, with >90% purity and suitable for SDS-PAGE, MS.
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Key facts
- Purity
- >90% SDS-PAGE
- Expression system
- Escherichia coli
- Tags
- His tag N-Terminus
- Applications
- SDS-PAGE, MS
- Biologically active
- No
Amino acid sequence
M R G S H H H H H H G M A S M T G G Q Q M G R D L Y D D D D K D R W G S I Y A L D C E M S Y T T Y G L E L T R V T V V D T D V H V V Y D T F V K P D N E I V D Y N T R F S G V T E A D L A D T S V T L R D V Q A V L L S M F S A D T I L I G H S L E S D L L A L K V I H S T V V D T S V L F P H R L G L P Y K R S L R N L M A D Y L R Q I I Q D N V D G H S S S E D A G A C M H L V I W K V R E D A K T K R
Reactivity data
| Application | Reactivity | Dilution info | Notes |
|---|---|---|---|
Application SDS-PAGE | Reactivity Reacts | Dilution info - | Notes - |
Application MS | Reactivity Reacts | Dilution info - | Notes - |
Target data
Function
Seems to have no detectable effect on transcription elongation in vitro.
Alternative names
ELOABP1, KIAA1138, TCEB3BP1, REXO1, RNA exonuclease 1 homolog, Elongin-A-binding protein 1, Transcription elongation factor B polypeptide 3-binding protein 1, EloA-BP1
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Recombinant Human REXO1 protein is a Human Fragment protein, in the 1060 to 1221 aa range, expressed in Escherichia coli, with >90% purity and suitable for SDS-PAGE, MS.
Key facts
- Purity
- >90% SDS-PAGE
- Expression system
- Escherichia coli
- Tags
- His tag N-Terminus
- Applications
- SDS-PAGE, MS
- Biologically active
- No
- Accession
- Q8N1G1-1
- Animal free
- No
- Species
- Human
- Concentration
- Storage buffer
pH: 8
Constituents: 10% Glycerol (glycerin, glycerine), 0.88% Sodium chloride, 0.32% Tris HCl, 0.02% (R*,R*)-1,4-Dimercaptobutan-2,3-diol
Sequence info
Amino acid sequence
- M R G S H H H H H H G M A S M T G G Q Q M G R D L Y D D D D K D R W G S I Y A L D C E M S Y T T Y G L E L T R V T V V D T D V H V V Y D T F V K P D N E I V D Y N T R F S G V T E A D L A D T S V T L R D V Q A V L L S M F S A D T I L I G H S L E S D L L A L K V I H S T V V D T S V L F P H R L G L P Y K R S L R N L M A D Y L R Q I I Q D N V D G H S S S E D A G A C M H L V I W K V R E D A K T K R
- Accession
- Q8N1G1
- Protein length
- Fragment
- Predicted molecular weight
- 22.3 kDa
- Amino acids
- 1060 to 1221
- Nature
- Recombinant
- Tags
- His tag N-Terminus
Specifications
- Form
- Liquid
- Additional notes
ab177672 is purified using conventional chromatography techniques.
General info
- Function
Seems to have no detectable effect on transcription elongation in vitro.
- Sequence similarities
Belongs to the REXO1/REXO3 family.
- Subcellular localisation
- Nucleus
Storage
- Shipped at conditions
- Blue Ice
- Appropriate short-term storage duration
- 1-2 weeks
- Appropriate short-term storage conditions
- +4°C
- Appropriate long-term storage conditions
- -20°C
- Aliquoting information
- Upon delivery aliquot
- Storage information
- Avoid freeze / thaw cycle
Supplementary info
- This supplementary information is collated from multiple sources and compiled automatically.
- Activity summary
REXO1 also known as RNA exonuclease 1 homolog is a protein primarily involved in RNA processing. It functions mechanistically as an exonuclease which means it helps cut and process RNA molecules by removing nucleotides from the ends of RNA. This protein has an approximate molecular mass of 126 kDa. Researchers have identified REXO1 expression in various tissues but it is especially present in the testis and ovary indicating roles in reproductive tissue functions.
- Biological function summary
REXO1 plays a significant role in maintaining RNA stability and regulating RNA quantity in cells. This protein does not operate alone; it is part of the exosome complex which is indispensable for RNA processing and degradation. Together with other proteins in the complex REXO1 contributes to the maturation of small RNAs and the degradation of defective mRNA molecules. By doing so the protein ensures the proper functioning of cellular RNA dynamics.
- Pathways
REXO1 is involved in RNA degradation pathways and the processing of ribosomal RNA (rRNA). Within these pathways it collaborates closely with proteins such as DIS3 and EXOSC10 which are also components of the exosome. This cooperation facilitates the turnover and processing of RNA transcripts which is essential for gene expression regulation. REXO1's involvement in these pathways highlights its integral role in managing RNA homeostasis in cells.
- Associated diseases and disorders
REXO1 has connections to certain reproductive system disorders and cancers. Mutations or dysregulation of this protein can impact fertility potentially leading to conditions like infertility. Its relationship with other proteins such as components of the exosome complex indicates a broader impact on cellular function and genome stability. Furthermore REXO1 is often observed in cancerous cells where it may contribute to the altered RNA metabolism that characterizes many cancer types.
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SDS-PAGE - Recombinant Human REXO1 protein (ab177672)
15% SDS-PAGE analysis of ab177672 (3μg).
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