Recombinant Human REXO1 protein (His tag N-Terminus)

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

REXO1 also known as RNA exonuclease 1 homolog is a protein primarily involved in RNA processing. It functions mechanistically as an exonuclease which means it helps cut and process RNA molecules by removing nucleotides from the ends of RNA. This protein has an approximate molecular mass of 126 kDa. Researchers have identified REXO1 expression in various tissues but it is especially present in the testis and ovary indicating roles in reproductive tissue functions.

Biological function summary

REXO1 plays a significant role in maintaining RNA stability and regulating RNA quantity in cells. This protein does not operate alone; it is part of the exosome complex which is indispensable for RNA processing and degradation. Together with other proteins in the complex REXO1 contributes to the maturation of small RNAs and the degradation of defective mRNA molecules. By doing so the protein ensures the proper functioning of cellular RNA dynamics.

Pathways

REXO1 is involved in RNA degradation pathways and the processing of ribosomal RNA (rRNA). Within these pathways it collaborates closely with proteins such as DIS3 and EXOSC10 which are also components of the exosome. This cooperation facilitates the turnover and processing of RNA transcripts which is essential for gene expression regulation. REXO1's involvement in these pathways highlights its integral role in managing RNA homeostasis in cells.

REXO1 has connections to certain reproductive system disorders and cancers. Mutations or dysregulation of this protein can impact fertility potentially leading to conditions like infertility. Its relationship with other proteins such as components of the exosome complex indicates a broader impact on cellular function and genome stability. Furthermore REXO1 is often observed in cancerous cells where it may contribute to the altered RNA metabolism that characterizes many cancer types.