Recombinant Human RFX5 protein
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Recombinant Human RFX5 protein is a Human Full Length protein, in the 1 to 616 aa range, expressed in Wheat germ, suitable for SDS-PAGE, ELISA, WB.
View Alternative Names
DNA-binding protein RFX5, Regulatory factor X 5, RFX5
- SDS-PAGE
Unknown
SDS-PAGE - Recombinant Human RFX5 protein (AB131776)
12.5% SDS-PAGE analysis of ab131776 stained with Coomassie Blue.
Reactivity data
Sequence info
Properties and storage information
Shipped at conditions
Appropriate short-term storage conditions
Appropriate long-term storage conditions
Aliquoting information
Storage information
Supplementary information
This supplementary information is collated from multiple sources and compiled automatically.
Biological function summary
RFX5 functions as part of the RFX complex an important element for the transcription of MHC class II genes. It interacts with other regulatory factor X proteins to form this complex enabling the activation of target gene transcription. RFX5 acts by binding to the X box motifs within the promoters of the MHC class II genes. Its presence is necessary to maintain the immune response capability by ensuring the expression of these genes which is a fundamental process in antigen presentation to immune cells.
Pathways
RFX5 integrates into the MHC class II antigen presentation pathway. It has a significant relationship with the CIITA transcriptional regulator with CIITA enhancing the activity of RFX5 during the assembly of the MHC class II transcriptional machinery. Another important pathway is the immune response pathway where RFX5 is important in coordinating the expression of genes that help the immune system recognize and respond to pathogens effectively.
Specifications
Form
Liquid
General info
Function
Activates transcription from class II MHC promoters. Recognizes X-boxes. Mediates cooperative binding between RFX and NF-Y. RFX binds the X1 box of MHC-II promoters.
Sequence similarities
Belongs to the RFX family.
Post-translational modifications
Phosphorylated.
Subcellular localisation
Nucleus
Target data
Complementary Products
Product promise
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