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AB164485

Recombinant Human RGD1310794 protein

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Recombinant Human RGD1310794 protein is a Human Full Length protein, in the 1 to 367 aa range, expressed in Wheat germ, suitable for ELISA, WB.

View Alternative Names

C7orf64, HSPC304, RBM48, RNA-binding protein 48

1 Images
SDS-PAGE - Recombinant Human RGD1310794 protein (AB164485)
  • SDS-PAGE

Unknown

SDS-PAGE - Recombinant Human RGD1310794 protein (AB164485)

ab164485 on a 12.5% SDS-PAGE stained with Coomassie Blue.

Key facts

Expression system

Wheat germ

Tags

GST tag N-Terminus

Applications

WB, ELISA

applications

Biologically active

No

Accession

Q5RL73

Animal free

No

Carrier free

No

Species

Human

Storage buffer

pH: 8 Constituents: 0.79% Tris HCl, 0.31% Glutathione

storage-buffer

Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "ELISA": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "WB": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }

Sequence info

[{"sequence":"MASSGGELGSLFDHHVQRAVCDTRAKYREGRRPRAVKVYTINLESQYLLIQGVPAVGVMKELVERFALYGAIEQYNALDEYPAEDFTEVYLIKFMNLQSARTAKRKMDEQSFFGGLLHVCYAPEFETVEETRKKLQMRKAYVVKTTENKDHYVTKKKLVTEHKDTEDFRQDFHSEMSGFCKAALNTSAGNSNPYLPYSCELPLCYFSSKCMCSSGGPVDRAPDSSKDGRNHHKTMGHYNHNDSLRKTQINSLKNSVACPGAQKAITSSEAVDRFMPRTTQLQERKRRREDDRKLGTFLQTNPTGNEIMIGPLLPDISKVDMHDDSLNTTANLIRHKLKEVISSVPKPPEDKPEDVHTSHPLKQRRRI","proteinLength":"Full Length","predictedMolecularWeight":null,"actualMolecularWeight":null,"aminoAcidEnd":367,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"Wheat germ","accessionNumber":"Q5RL73","tags":[{"tag":"GST","terminus":"N-Terminus"}]}]

Properties and storage information

Shipped at conditions
Dry Ice
Appropriate short-term storage conditions
-80°C
Appropriate long-term storage conditions
-80°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
False

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

RGD1310794 also known as Bcl-2-associated death promoter weighs around 23 kDa. This protein is expressed in various tissues throughout the body including the lymphatic tissues and the nervous system. Mechanically it promotes apoptosis by interacting with other proteins in the Bcl-2 family. Its expression increases in response to certain cellular stress signals aiding in the regulation of cell death processes.
Biological function summary

The protein plays a significant role in the apoptotic pathway as it is part of the pro-apoptotic complex. It enhances the release of cytochrome c from the mitochondria which is a critical step in apoptosis. When Bcl-2-associated death promoter forms complexes with Bax and Bak mitochondrial outer membrane permeabilization occurs. This function helps regulate cell populations and eliminates damaged or vulnerable cells.

Pathways

RGD1310794 is instrumental in the intrinsic apoptotic signaling pathway. It works closely with proteins such as Bax and Bak in mediating mitochondrial pathway activation. This pathway is essential for maintaining cellular homeostasis and is especially critical in tissue development and immune system balance.

Dysregulation of RGD1310794 activity is associated with cancer and neurodegenerative diseases. In cancer improper regulation of apoptosis can lead to uncontrolled cell growth making the apoptotic function of RGD1310794 highly relevant. In neurodegenerative conditions like Alzheimer's disease excessive apoptosis might contribute to neuronal loss. Proteins such as Bcl-2 which are known to oppose the action of RGD1310794 often play a role in the progression of these diseases.

Specifications

Form

Liquid

General info

Function

As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs.

Sequence similarities

Belongs to the RBM48 family.

Product protocols

Target data

As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs.
See full target information RBM48

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