Recombinant Human RGS1 protein is a Human Full Length protein, in the 1 to 209 aa range, expressed in Escherichia coli, with >90% purity and suitable for SDS-PAGE, MS.
Images
Key facts
- Purity
- >90% SDS-PAGE
- Expression system
- Escherichia coli
- Tags
- His tag N-Terminus
- Applications
- SDS-PAGE, MS
- Biologically active
- No
Amino acid sequence
M G S S H H H H H H S S G L V P R G S H M G S H M R A A A I S T P K L D K M P G M F F S A N P K E L K G T T H S L L D D K M Q K R R P K T F G M D M K A Y L R S M I P H L E S G M K S S K S K D V L S A A E V M Q W S Q S L E K L L A N Q T G Q N V F G S F L K S E F S E E N I E F W L A C E D Y K K T E S D L L P C K A E E I Y K A F V H S D A A K Q I N I D F R T R E S T A K K I K A P T P T C F D E A Q K V I Y T L M E K D S Y P R F L K S D I Y L N L L N D L Q A N S L K
Reactivity data
| Application | Reactivity | Dilution info | Notes |
|---|---|---|---|
Application SDS-PAGE | Reactivity Reacts | Dilution info - | Notes - |
Application MS | Reactivity Reacts | Dilution info - | Notes - |
Associated Products
Select an associated product type
1 product for Alternative Product
Target data
Function
Regulates G protein-coupled receptor signaling cascades, including signaling downstream of the N-formylpeptide chemoattractant receptors and leukotriene receptors (PubMed:10480894). Inhibits B cell chemotaxis toward CXCL12 (By similarity). Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form (PubMed:10480894, PubMed:18434541).
Alternative names
1R20, BL34, IER1, RGS1, Regulator of G-protein signaling 1, B-cell activation protein BL34, Early response protein 1R20
Recommended products
Recombinant Human RGS1 protein is a Human Full Length protein, in the 1 to 209 aa range, expressed in Escherichia coli, with >90% purity and suitable for SDS-PAGE, MS.
Key facts
- Purity
- >90% SDS-PAGE
- Expression system
- Escherichia coli
- Tags
- His tag N-Terminus
- Applications
- SDS-PAGE, MS
- Biologically active
- No
- Accession
- Q08116-1
- Animal free
- No
- Species
- Human
- Concentration
- Storage buffer
pH: 8
Constituents: 10% Glycerol (glycerin, glycerine), 0.88% Sodium chloride, 0.32% Tris HCl, 0.02% (R*,R*)-1,4-Dimercaptobutan-2,3-diol
Sequence info
Amino acid sequence
- M G S S H H H H H H S S G L V P R G S H M G S H M R A A A I S T P K L D K M P G M F F S A N P K E L K G T T H S L L D D K M Q K R R P K T F G M D M K A Y L R S M I P H L E S G M K S S K S K D V L S A A E V M Q W S Q S L E K L L A N Q T G Q N V F G S F L K S E F S E E N I E F W L A C E D Y K K T E S D L L P C K A E E I Y K A F V H S D A A K Q I N I D F R T R E S T A K K I K A P T P T C F D E A Q K V I Y T L M E K D S Y P R F L K S D I Y L N L L N D L Q A N S L K
- Accession
- Q08116
- Protein length
- Full Length
- Predicted molecular weight
- 26 kDa
- Amino acids
- 1 to 209
- Nature
- Recombinant
- Tags
- His tag N-Terminus
Specifications
- Form
- Liquid
- Additional notes
ab126697 is purified by conventional chromatography techniques.
General info
- Function
Regulates G protein-coupled receptor signaling cascades, including signaling downstream of the N-formylpeptide chemoattractant receptors and leukotriene receptors (PubMed:10480894). Inhibits B cell chemotaxis toward CXCL12 (By similarity). Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form (PubMed:10480894, PubMed:18434541).
Storage
- Shipped at conditions
- Blue Ice
- Appropriate short-term storage duration
- 1-2 weeks
- Appropriate short-term storage conditions
- +4°C
- Appropriate long-term storage conditions
- -20°C
- Aliquoting information
- Upon delivery aliquot
- Storage information
- Avoid freeze / thaw cycle
Supplementary info
- This supplementary information is collated from multiple sources and compiled automatically.
- Activity summary
Regulator of G-protein signaling 1 (RGS1) also known as BL34 or 1R20 acts mechanically as a GTPase-activating protein (GAP) for Gα subunits of heterotrimeric G-proteins. This function speeds up the deactivation of G-proteins by converting GTP to GDP effectively stopping signal transduction. RGS1 has a molecular mass of approximately 25 kDa. This protein is mainly expressed in B and T lymphocytes and you can find it in lymphoid tissues such as the spleen and lymph nodes.
- Biological function summary
The RGS1 protein modulates immune cell signaling thereby controlling cell migration and positioning. RGS1 plays a role in reducing signaling from chemokine receptors which affects the movement of lymphocytes within tissues. It does not significantly form part of a larger complex mostly acting independently to exert its function within the immune system.
- Pathways
The regulatory activity of RGS1 heavily influences the chemokine signaling pathway and the G-protein coupled receptor (GPCR) signaling pathway. These pathways are important for the directional migration and activation of immune cells. Within these pathways RGS1 interacts with related proteins such as CXCR4 and Gα subunits modulating their signaling outputs to regulate immune cell responses.
- Associated diseases and disorders
RGS1 links to autoimmune diseases and certain cancers. It can modulate the immune response in diseases such as multiple sclerosis where its activity may affect immune cell movement and function. Connections also exist between RGS1 and CXCR4 within cancer pathology where altered signaling could contribute to tumor growth and metastasis. By affecting these pathways RGS1 becomes a potential target for therapeutic intervention in related disorders.
Product promise
We are dedicated to supporting your work with high quality reagents and we are here for you every step of the way should you need us.
In the unlikely event of one of our products not working as expected, you are covered by our product promise.
Full details and terms and conditions can be found here:
Terms & Conditions.
1 product image
SDS-PAGE - Recombinant Human RGS1 protein (ab126697)
15% SDS-PAGE analysis of 3 µg of ab126697 (RGS1 protein).
Downloads
Product protocols
- Visit the general protocols
- Visit troubleshooting
Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.
For licensing inquiries, please contact partnerships@abcam.com