Recombinant Human RGS19 protein

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

RGS19 also known as regulator of G protein signaling 19 or GAIP (G Alpha Interacting Protein) is a member of the RGS family of proteins. It has a molecular weight of approximately 24 kDa. RGS19 primarily functions as a GTPase-activating protein (GAP) which accelerates the deactivation of G protein-coupled receptors (GPCRs) by increasing the rate of GTP hydrolysis on the alpha subunit of heterotrimeric G proteins. This regulatory protein primarily expresses in tissues like the brain lungs and heart where it plays a role in modulating signal transduction.

Biological function summary

The function of RGS19 plays an important role in controlling signal durations initiated by GPCRs. The protein is involved in the regulation of various signaling pathways that govern essential cellular processes such as cell differentiation and proliferation. RGS19 forms part of a larger complex with other cellular components where its interactions help modulate the intensity and duration of signals that influence cellular outcomes aiming at maintaining physiological balance.

Pathways

RGS19 integrates into pathways like the MAPK/ERK pathway and the cAMP signaling pathway. Within these pathways it modulates the activity by interacting with G alpha subunits impacting downstream signaling events. The protein is associated with proteins such as GNAI3 and GNAZ which further connects RGS19 to intricate networks of signaling molecules that ultimately regulate physiological functions.

Studies indicate RGS19 may be implicated in cancer and cardiovascular diseases. Aberrant regulation of RGS19 might influence cancer progression linking it to pathways that regulate cell growth and survival. Additionally it connects through its association with other proteins like GNAI3 where dysregulation can contribute to cardiovascular disease potentially affecting heart rhythm and function. Continual research focuses on understanding these associations to inform potential therapeutic strategies.