Recombinant Human RGS19 protein is a Human Full Length protein, in the 1 to 217 aa range, expressed in Escherichia coli, with >90% purity and suitable for SDS-PAGE, MS.
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Key facts
- Purity
- >90% SDS-PAGE
- Expression system
- Escherichia coli
- Tags
- His tag N-Terminus
- Applications
- SDS-PAGE, MS
- Biologically active
- No
Amino acid sequence
M G S S H H H H H H S S G L V P R G S H M P T P H E A E K Q I T G P E E A D R P P S M S S H D T A S P A A P S R N P C C L C W C C C C S C S W N Q E R R R A W Q A S R E S K L Q P L P S C E V C A T P S P E E V Q S W A Q S F D K L M H S P A G R S V F R A F L R T E Y S E E N M L F W L A C E E L K A E A N Q H V V D E K A R L I Y E D Y V S I L S P K E V S L D S R V R E G I N K K M Q E P S A H T F D D A Q L Q I Y T L M H R D S Y P R F L S S P T Y R A L L L Q G P S Q S S S E A
Reactivity data
| Application | Reactivity | Dilution info | Notes |
|---|---|---|---|
Application SDS-PAGE | Reactivity Reacts | Dilution info - | Notes - |
Application MS | Reactivity Reacts | Dilution info - | Notes - |
Target data
Function
Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Binds to G-alpha subfamily 1 members, with the order G(i)a3 > G(i)a1 > G(o)a >> G(z)a/G(i)a2. Activity on G(z)-alpha is inhibited by phosphorylation and palmitoylation of the G-protein.
Alternative names
GAIP, GNAI3IP, RGS19, Regulator of G-protein signaling 19, G-alpha-interacting protein
Recommended products
Recombinant Human RGS19 protein is a Human Full Length protein, in the 1 to 217 aa range, expressed in Escherichia coli, with >90% purity and suitable for SDS-PAGE, MS.
Key facts
- Purity
- >90% SDS-PAGE
- Expression system
- Escherichia coli
- Tags
- His tag N-Terminus
- Applications
- SDS-PAGE, MS
- Biologically active
- No
- Accession
- P49795-1
- Animal free
- No
- Species
- Human
- Concentration
- Storage buffer
pH: 7.4
Constituents: PBS, 10% Glycerol (glycerin, glycerine)
Sequence info
Amino acid sequence
- M G S S H H H H H H S S G L V P R G S H M P T P H E A E K Q I T G P E E A D R P P S M S S H D T A S P A A P S R N P C C L C W C C C C S C S W N Q E R R R A W Q A S R E S K L Q P L P S C E V C A T P S P E E V Q S W A Q S F D K L M H S P A G R S V F R A F L R T E Y S E E N M L F W L A C E E L K A E A N Q H V V D E K A R L I Y E D Y V S I L S P K E V S L D S R V R E G I N K K M Q E P S A H T F D D A Q L Q I Y T L M H R D S Y P R F L S S P T Y R A L L L Q G P S Q S S S E A
- Accession
- P49795
- Protein length
- Full Length
- Predicted molecular weight
- 26.7 kDa
- Amino acids
- 1 to 217
- Nature
- Recombinant
- Tags
- His tag N-Terminus
Specifications
- Form
- Liquid
- Additional notes
ab101949 is purified using conventional chromatography techniques.
General info
- Function
Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Binds to G-alpha subfamily 1 members, with the order G(i)a3 > G(i)a1 > G(o)a >> G(z)a/G(i)a2. Activity on G(z)-alpha is inhibited by phosphorylation and palmitoylation of the G-protein.
- Post-translational modifications
Fatty acylated. Heavily palmitoylated in the cysteine string motif.
Storage
- Shipped at conditions
- Blue Ice
- Appropriate short-term storage conditions
- -20°C
- Appropriate long-term storage conditions
- -20°C
- Aliquoting information
- Upon delivery aliquot
- Storage information
- Avoid freeze / thaw cycle
Supplementary info
- This supplementary information is collated from multiple sources and compiled automatically.
- Activity summary
RGS19 also known as regulator of G protein signaling 19 or GAIP (G Alpha Interacting Protein) is a member of the RGS family of proteins. It has a molecular weight of approximately 24 kDa. RGS19 primarily functions as a GTPase-activating protein (GAP) which accelerates the deactivation of G protein-coupled receptors (GPCRs) by increasing the rate of GTP hydrolysis on the alpha subunit of heterotrimeric G proteins. This regulatory protein primarily expresses in tissues like the brain lungs and heart where it plays a role in modulating signal transduction.
- Biological function summary
The function of RGS19 plays an important role in controlling signal durations initiated by GPCRs. The protein is involved in the regulation of various signaling pathways that govern essential cellular processes such as cell differentiation and proliferation. RGS19 forms part of a larger complex with other cellular components where its interactions help modulate the intensity and duration of signals that influence cellular outcomes aiming at maintaining physiological balance.
- Pathways
RGS19 integrates into pathways like the MAPK/ERK pathway and the cAMP signaling pathway. Within these pathways it modulates the activity by interacting with G alpha subunits impacting downstream signaling events. The protein is associated with proteins such as GNAI3 and GNAZ which further connects RGS19 to intricate networks of signaling molecules that ultimately regulate physiological functions.
- Associated diseases and disorders
Studies indicate RGS19 may be implicated in cancer and cardiovascular diseases. Aberrant regulation of RGS19 might influence cancer progression linking it to pathways that regulate cell growth and survival. Additionally it connects through its association with other proteins like GNAI3 where dysregulation can contribute to cardiovascular disease potentially affecting heart rhythm and function. Continual research focuses on understanding these associations to inform potential therapeutic strategies.
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1 product image
SDS-PAGE - Recombinant Human RGS19 protein (ab101949)
15% SDS-PAGE analysis of 3μg ab101949.
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