Recombinant Human RGS4 protein
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Recombinant Human RGS4 protein is a Human Full Length protein, in the 1 to 205 aa range, expressed in Escherichia coli, with >90%, suitable for SDS-PAGE, Mass Spec.
View Alternative Names
Regulator of G-protein signaling 4, RGP4, RGS4
- SDS-PAGE
Supplier Data
SDS-PAGE - Recombinant Human RGS4 protein (AB113136)
3ug by SDS-PAGE under reducing condition and visualized by coomassie blue stain.
Reactivity data
Sequence info
Properties and storage information
Shipped at conditions
Appropriate short-term storage duration
Appropriate short-term storage conditions
Appropriate long-term storage conditions
Aliquoting information
Storage information
Supplementary information
This supplementary information is collated from multiple sources and compiled automatically.
Biological function summary
RGS proteins including RGS4 play an important role in modulating GPCR signaling by serving as GTPase-activating proteins (GAPs) for Gα subunits. RGS4 directly influences neurotransmission and signal transduction pathways by turning off G-protein activity affecting processes like mood regulation and cardiac function. Although RGS4 does not form part of a stable complex it dynamically interacts with G-proteins during signal transmission allowing it to impact various signaling pathways temporarily.
Pathways
Several signaling cascades depend on RGS4 for efficient function. It is closely involved in the MAPK signaling pathway which affects numerous cellular responses and the phosphatidylinositol signaling system which helps regulate intracellular calcium levels. These pathways link RGS4 to proteins such as Raf kinases and PLC-β which are key players in transducing signals from the cell surface to intracellular targets.
Specifications
Form
Liquid
Additional notes
ab113136 was purified using conventional chromatography techniques.
General info
Function
Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Activity on G(z)-alpha is inhibited by phosphorylation of the G-protein. Activity on G(z)-alpha and G(i)-alpha-1 is inhibited by palmitoylation of the G-protein.
Post-translational modifications
Palmitoylated on Cys-2 and/or Cys-12.. Phosphorylated by cyclic GMP-dependent protein kinase.
Target data
Complementary Products
Product promise
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