JavaScript is disabled in your browser. Please enable JavaScript to view this website.
AB159342

Recombinant Human RGS7 protein

Be the first to review this product! Submit a review

|

(0 Publication)

Recombinant Human RGS7 protein is a Human Full Length protein, in the 1 to 487 aa range, expressed in Wheat germ, suitable for ELISA, WB.

View Alternative Names

Regulator of G-protein signaling 7, RGS7

1 Images
SDS-PAGE - Recombinant Human RGS7 protein (AB159342)
  • SDS-PAGE

Unknown

SDS-PAGE - Recombinant Human RGS7 protein (AB159342)

ab159342 on a 12.5% SDS-PAGE stained with Coomassie Blue.

Key facts

Expression system

Wheat germ

Tags

GST tag N-Terminus

Applications

ELISA, WB

applications

Biologically active

No

Accession

P49802

Animal free

No

Carrier free

No

Species

Human

Storage buffer

pH: 8 Constituents: 0.79% Tris HCl, 0.31% Glutathione

storage-buffer

style
left-column

Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "ELISA": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "WB": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
style
left-column
style
left-column

Sequence info

[{"sequence":"MAQGNNYGQTSNGVADESPNMLVYRKMEDVIARMQDEKNGIPIRTVKSFLSKIPSVFSGSDIVQWLIKNLTIEDPVEALHLGTLMAAHGYFFPISDHVLTLKDDGTFYRFQTPYFWPSNCWEPENTDYAVYLCKRTMQNKARLELADYEAESLARLQRAFARKWEFIFMQAEAQAKVDKKRDKIERKILDSQERAFWDVHRPVPGCVNTTEVDIKKSSRMRNPHKTRKSVYGLQNDIRSHSPTHTPTPETKPPTEDELQQQIKYWQIQLDRHRLKMSKVADSLLSYTEQYLEYDPFLLPPDPSNPWLSDDTTFWELEASKEPSQQRVKRWGFGMDEALKDPVGREQFLKFLESEFSSENLRFWLAVEDLKKRPIKEVPSRVQEIWQEFLAPGAPSAINLDSKSYDKTTHNVKEPGRYTFEDAQEHIYKLMKSDSYPRFIRSSAYQELLQAKKKSGNSMDRRTSFEKFAQNVGKSLTSKRLTSLAQSY","proteinLength":"Full Length","predictedMolecularWeight":null,"actualMolecularWeight":null,"aminoAcidEnd":487,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"Wheat germ","accessionNumber":"P49802","tags":[{"tag":"GST","terminus":"N-Terminus"}]}]
style
left-column

Properties and storage information

Shipped at conditions
Dry Ice
Appropriate short-term storage conditions
-80°C
Appropriate long-term storage conditions
-80°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
False
style
left-column

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Regulator of G protein signaling 7 (RGS7) also known as RGP7 is a member of the R7 family of RGS proteins with a molecular weight of approximately 85 kDa. RGS7 regulates G protein signaling by accelerating the deactivation of Gα subunits through its GTPase-activating protein activity. It is widely expressed in the central nervous system especially in the brain regions like the hippocampus and basal ganglia.
Biological function summary

G protein-coupled receptor (GPCR) signaling modulation is an important role of RGS7. It forms a complex with the Gβ5 subunit and other anchoring proteins to regulate synaptic transmission and neuronal excitability. This complex localizes to synaptic sites and modifies neurotransmitter release which can influence cognitive functions and behaviors. RGS7 helps in maintaining signal fidelity within neural circuits.

Pathways

G protein-coupled receptor signaling and neurotransmitter release are two important biological pathways involving RGS7. In the GPCR signaling pathway RGS7 modulates GPCR response by interacting with Gα subunits to accelerate their inactivation. Interaction with neurotransmitter release pathways occurs as RGS7 controls calcium influx and synaptic vesicle fusion. It relates to proteins such as Gβ5 and other G protein subunits playing key roles in these pathways.

Research indicates that RGS7 is connected to certain neurological conditions such as addiction and depression. Dysregulation of RGS7 may alter neurotransmitter systems influencing susceptibility to addictive substances and mood disorders. RGS7 interacts with proteins such as Gβ5 which are also involved in the dysregulation seen in these conditions. Understanding the functions of RGS7 can inform therapeutic strategies for these diseases.
style
left-column

Specifications

Form

Liquid

style
left-column

General info

Function

GTPase activator component of the RGS7-GNB5 complex that regulates G protein-coupled receptor signaling cascades (PubMed : 10521509, PubMed : 10862767, PubMed : 31189666). The RGS7-GNB5 complex acts as an inhibitor signal transduction by promoting the GTPase activity of G protein alpha subunits, such as GNAO1, thereby driving them into their inactive GDP-bound form (PubMed : 10521509, PubMed : 10862767). May play a role in synaptic vesicle exocytosis (Probable) (PubMed : 12659861). Glycine-dependent regulation of the RGS7-GNB5 complex by GPR158 affects mood and cognition via its ability to regulate neuronal excitability in L2/L3 pyramidal neurons of the prefrontal cortex (By similarity). Modulates the activity of potassium channels that are activated by GNAO1 in response to muscarinic acetylcholine receptor M2/CHRM2 signaling (PubMed : 15897264).

Post-translational modifications

Palmitoylated.. Ubiquitinated, leading to rapid proteasomal degradation.. Phosphorylation and subsequent interaction with 14-3-3 proteins inhibits GAP activity.

style
left-column

Product protocols

style
left-column

Target data

GTPase activator component of the RGS7-GNB5 complex that regulates G protein-coupled receptor signaling cascades (PubMed : 10521509, PubMed : 10862767, PubMed : 31189666). The RGS7-GNB5 complex acts as an inhibitor signal transduction by promoting the GTPase activity of G protein alpha subunits, such as GNAO1, thereby driving them into their inactive GDP-bound form (PubMed : 10521509, PubMed : 10862767). May play a role in synaptic vesicle exocytosis (Probable) (PubMed : 12659861). Glycine-dependent regulation of the RGS7-GNB5 complex by GPR158 affects mood and cognition via its ability to regulate neuronal excitability in L2/L3 pyramidal neurons of the prefrontal cortex (By similarity). Modulates the activity of potassium channels that are activated by GNAO1 in response to muscarinic acetylcholine receptor M2/CHRM2 signaling (PubMed : 15897264).
See full target information Regulator of G-protein signaling 7
style
left-column
style
left-column
style
right-column

Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.
For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com