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AB131677

Recombinant Human RhoV protein (denatured) (His tag N-Terminus)

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Recombinant Human RhoV protein (denatured) (His tag N-Terminus) is a Human Full Length protein, in the 1 to 236 aa range, expressed in Escherichia coli, with >85%, suitable for SDS-PAGE.

View Alternative Names

ARHV, WRCH2, RHOV, Rho-related GTP-binding protein RhoV, CDC42-like GTPase 2, GTP-binding protein-like 2, Rho GTPase-like protein ARHV, Wnt-1 responsive Cdc42 homolog 2, WRCH-2

1 Images
SDS-PAGE - Recombinant Human RhoV protein (denatured) (His tag N-Terminus) (AB131677)
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SDS-PAGE - Recombinant Human RhoV protein (denatured) (His tag N-Terminus) (AB131677)

15% SDS-PAGE analysis of 3 µg ab131677.

Key facts

Purity

>85% SDS-PAGE

Expression system

Escherichia coli

Tags

His tag N-Terminus

Applications

SDS-PAGE

applications

Biologically active

No

Accession

Q96L33

Animal free

No

Carrier free

No

Species

Human

Storage buffer

pH: 8 Constituents: 20% Glycerol (glycerin, glycerine), 12.01% Urea, 0.58% Sodium chloride, 0.32% Tris HCl, 0.02% (R*,R*)-1,4-Dimercaptobutan-2,3-diol

storage-buffer

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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Sequence info

[{"sequence":"MGSSHHHHHHSSGLVPRGSHMGSMPPRELSEAEPPPLRAPTPPPRRRSAPPELGIKCVLVGDGAVGKSSLIVSYTCNGYPARYRPTALDTFSVQVLVDGAPVRIELWDTAGQEDFDRLRSLCYPDTDVFLACFSVVQPSSFQNITEKWLPEIRTHNPQAPVLLVGTQADLRDDVNVLIQLDQGGREGPVPQPQAQGLAEKIRACCYLECSALTQKNLKEVFDSAILSAIEHKARLEKKLNAKGVRTLSRCRWKKFFCFV","proteinLength":"Full Length","predictedMolecularWeight":"28.6 kDa","actualMolecularWeight":null,"aminoAcidEnd":236,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"Escherichia coli","accessionNumber":"Q96L33","tags":[{"tag":"His","terminus":"N-Terminus"}]}]
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Properties and storage information

Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

RhoV also known as Chp (Cdc42 homologous protein) is a member of the Rho GTPase family with a molecular mass of approximately 21 kDa. It functions as a molecular switch cycling between an active GTP-bound form and an inactive GDP-bound form. RhoV is mainly expressed in the skin hair follicles and certain cancer cell lines. The protein is involved in actin cytoskeleton organization affecting cell shape and motility.
Biological function summary

This protein plays a role in cellular processes like morphogenesis and differentiation. RhoV interacts with other proteins in cellular signaling pathways including effector proteins like PAKs (p21-activated kinases). It is not typically associated with large protein complexes but modulates actin and microtubule arrays important for proper cell division and migration.

Pathways

Many researchers link RhoV to the JNK (c-Jun N-terminal kinase) and ERK (extracellular signal-regulated kinase) signaling pathways. In the JNK pathway RhoV activates JNK kinases which are involved in processes like stress response and apoptosis. Additionally its interactions within the ERK pathway help regulate cell proliferation and differentiation. RhoV coordinates with proteins such as Rac1 and Cdc42 other Rho GTPases with similar functions.

RhoV shows a connection with cancer and skin-related conditions. Increased expression of RhoV may support tumor growth and metastasis in malignant melanoma. In these contexts RhoV often influences pathways associated with other proteins like Ras a well-known regulator of cell proliferation and survival in cancer cells. Researchers also explore its involvement in skin disorders related with abnormal keratinocyte differentiation. Understanding RhoV's interactions with these proteins could provide insights into its role in these conditions.
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Specifications

Form

Liquid

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General info

Function

Plays a role in the control of the actin cytoskeleton via activation of the JNK pathway.

Sequence similarities

Belongs to the small GTPase superfamily. Rho family.

Subcellular localisation

Endosome membrane

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Product protocols

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Target data

Plays a role in the control of the actin cytoskeleton via activation of the JNK pathway.
See full target information RHOV
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